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| ZNF184 | Zinc finger protein 184; May be involved in transcriptional regulation; Zinc fingers C2H2-type (751 aa) | |||
| ZNF141 | Zinc finger protein 141; May be involved in transcriptional regulation as a repressor. Plays a role in limb development; Belongs to the krueppel C2H2-type zinc-finger protein family (474 aa) | |||
| ZNF430 | Zinc finger protein 430; May be involved in transcriptional regulation; Zinc fingers C2H2-type (570 aa) | |||
| WDR59 | GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1; Belongs to the WD repeat WDR59 family (974 aa) | |||
| EED | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two ep [...] (441 aa) | |||
| ZKSCAN7 | Zinc finger protein with KRAB and SCAN domains 7; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (754 aa) | |||
| ZNF117 | Zinc finger protein 117; May be involved in transcriptional regulation; Zinc fingers C2H2-type (483 aa) | |||
| ZNF585A | Zinc finger protein 585A; May be involved in transcriptional regulation; Zinc fingers C2H2-type (769 aa) | |||
| ZNF91 | Zinc finger protein 91; Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons- recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1. May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo; Belongs to the krueppel C2H2-type zinc-finger protein family (1191 aa) | |||
| ZNF138 | Zinc finger protein 138; May be involved in transcriptional regulation as a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family (319 aa) | |||
| ZNF431 | Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5’-GCGCCC-3’ in the promoter of PTCH1 (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family (576 aa) | |||
| ZNF680 | Zinc finger protein 680; May be involved in transcriptional regulation; Zinc fingers C2H2-type (530 aa) | |||
| ZNF624 | Zinc finger protein 624; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (865 aa) | |||
| ZNF85 | Zinc finger protein 85; May be a transcriptional repressor; Zinc fingers C2H2-type (595 aa) | |||
| ZNF84 | Zinc finger protein 84; May be involved in transcriptional regulation; Zinc fingers C2H2-type (738 aa) | |||
| ZNF92 | Zinc finger protein 92; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (586 aa) | |||
| ZNF479 | Zinc finger protein 479; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (524 aa) | |||
| ZNF486 | Zinc finger protein 486; May be involved in transcriptional regulation; Zinc fingers C2H2-type (463 aa) | |||
| ZNF695 | Zinc finger protein 695; May be involved in transcriptional regulation; Zinc fingers C2H2-type (515 aa) | |||
| ZNF93 | Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons- recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5’ end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...] (620 aa) | |||
| ZFP30 | Zinc finger protein 30 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type (519 aa) | |||
| ZNF708 | Zinc finger protein 708; May be involved in transcriptional regulation; Zinc fingers C2H2-type (563 aa) | |||
| DCAF10 | DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors (559 aa) | |||
| SIN3B | Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (1162 aa) | |||
| SIN3A | Paired amphipathic helix protein Sin3a; Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates wit [...] (1273 aa) | |||
| ZNF519 | Zinc finger protein 519; May be involved in transcriptional regulation; Zinc fingers C2H2-type (540 aa) | |||
