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  • 11.0 [archived version]
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ENSG00000272617 ENSG00000272617 SLC2A8 SLC2A8 ENSG00000260371 ENSG00000260371 PTPN11 PTPN11 PHACTR1 PHACTR1 SLC2A12 SLC2A12 SLC2A10 SLC2A10 SLC2A6 SLC2A6 SLC2A13 SLC2A13 COG8 COG8 PHACTR4 PHACTR4 MYH11 MYH11 PIGS PIGS PHACTR3 PHACTR3 PHACTR2 PHACTR2 DSP DSP OVCA2 OVCA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC2A12Solute carrier family 2, facilitated glucose transporter member 12; Facilitative glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily (617 aa)
SLC2A13Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family (648 aa)
COG8Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function; Components of oligomeric golgi complex (612 aa)
PIGSGPI transamidase component PIG-S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates; Belongs to the PIGS family (555 aa)
PHACTR1Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (580 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type (593 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10; Facilitative glucose transporter; Solute carriers (541 aa)
PHACTR3Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators (559 aa)
SLC2A6Solute carrier family 2, facilitated glucose transporter member 6; Facilitative glucose transporter; binds cytochalasin B with low affinity; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily (507 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8; Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity); Solute carriers (477 aa)
PHACTR4Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at ’Thr-320’. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to [...] (712 aa)
DSPDesmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family (2871 aa)
MYH11Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1979 aa)
PHACTR2Phosphatase and actin regulator 2 (645 aa)
ENSG00000260371Uncharacterized protein (156 aa)
ENSG00000272617Conserved oligomeric Golgi complex subunit 8 (164 aa)
OVCA2OVCA2, serine hydrolase domain containing; Belongs to the LovG family (227 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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