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STRINGSTRING
SPON1 SPON1 ADAMTS8 ADAMTS8 ADAMTS19 ADAMTS19 ADAMTS16 ADAMTS16 ADAMTS10 ADAMTS10 ADAMTS15 ADAMTS15 ADAMTS18 ADAMTS18 THSD7B THSD7B SBSPON SBSPON ADAMTS2 ADAMTS2 THSD4 THSD4 CFP CFP ADAMTSL2 ADAMTSL2 ADAMTS1 ADAMTS1 ADAMTS17 ADAMTS17 ADAMTS5 ADAMTS5 THBS1 THBS1 POFUT2 POFUT2 ADAMTS3 ADAMTS3 B3GALTL B3GALTL THBS2 THBS2 ADAMTSL5 ADAMTSL5 ADAMTS4 ADAMTS4 THSD1 THSD1 ADAMTSL4 ADAMTSL4 ADAMTSL3 ADAMTSL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CFPProperdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (469 aa)
ADAMTS2A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis; ADAM metallopeptidases with thrombospondin type 1 motif (1211 aa)
ADAMTS8A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties; ADAM metallopeptidases with thrombospondin type 1 motif (889 aa)
THSD1Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1 (852 aa)
THBS1Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity) (1170 aa)
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 (1095 aa)
ADAMTS10A disintegrin and metalloproteinase with thrombospondin motifs 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues; ADAM metallopeptidases with thrombospondin type 1 motif (1103 aa)
THSD7BThrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B (1608 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16 (1224 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19 (1207 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18 (1221 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the ’1938-Glu-|-Leu-1939’ site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif (967 aa)
ADAMTS5A disintegrin and metalloproteinase with thrombospondin motifs 5; Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle de [...] (930 aa)
ADAMTS3A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif (1205 aa)
ADAMTSL3ADAMTS-like protein 3; Immunoglobulin like domain containing (1691 aa)
SBSPONSomatomedin-B and thrombospondin type-1 domain-containing protein; Somatomedin B and thrombospondin type 1 domain containing; Belongs to the thrombospondin family (264 aa)
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15 (950 aa)
ADAMTSL5ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like (471 aa)
POFUT2GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and l [...] (429 aa)
B3GALTLBeta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (498 aa)
ADAMTSL2ADAMTS-like protein 2; ADAMTS like 2 (951 aa)
THSD4Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like (1018 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (1172 aa)
ADAMTS4A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-|-Ala-393’ site; ADAM metallopeptidases with thrombospondin type 1 motif (837 aa)
ADAMTSL4ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like (1097 aa)
SPON1Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell (807 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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