26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MRPS34	28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation (225 aa)
	MRPS25	Mitochondrial ribosomal protein S25 (173 aa)
	MRPS36	Mitochondrial ribosomal protein S36 (103 aa)
	MRPS9	Mitochondrial ribosomal protein S9 (396 aa)
	MRPS18B	Mitochondrial ribosomal protein S18B; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily (258 aa)
	AAGAB	Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR (315 aa)
	AP2S1	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold b [...] (142 aa)
	MRPS28	Mitochondrial ribosomal protein S28; Belongs to the bacterial ribosomal protein bS1 family (187 aa)
	MRPS18C	Mitochondrial ribosomal protein S18C (142 aa)
	GTPBP3	tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs (524 aa)
	MRPL37	Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family (423 aa)
	DAP3	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family (398 aa)
	MRPS18A	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily (196 aa)
	MRPS16	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family (137 aa)
	MRPS33	Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family (106 aa)
	RPS29	Ribosomal protein S29 (67 aa)
	MRPS6	Mitochondrial ribosomal protein S6 (125 aa)
	RPL17	60S ribosomal protein L17; Component of the large ribosomal subunit; Belongs to the universal ribosomal protein uL22 family (184 aa)
	MRPS14	Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family (128 aa)
	MRPL22	Mitochondrial ribosomal protein L22 (206 aa)
	ENSG00000276418	Tumor protein D52 (248 aa)
	C15orf57	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57 (194 aa)
	MRPS21	Mitochondrial ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family (87 aa)
	ENSG00000215472	RPL17-C18orf32 readthrough; Belongs to the universal ribosomal protein uL22 family (228 aa)
	C18orf32	RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family (190 aa)
	MRPL45	Mitochondrial ribosomal protein L45 (306 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAGAB	AP2S1	ENSP00000261880	ENSP00000263270	Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold b [...]	0.572
AAGAB	C15orf57	ENSP00000261880	ENSP00000452773	Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	0.825
AP2S1	AAGAB	ENSP00000263270	ENSP00000261880	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold b [...]	Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR	0.572
AP2S1	C15orf57	ENSP00000263270	ENSP00000452773	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold b [...]	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	0.816
C15orf57	AAGAB	ENSP00000452773	ENSP00000261880	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR	0.825
C15orf57	AP2S1	ENSP00000452773	ENSP00000263270	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold b [...]	0.816
C15orf57	MRPS14	ENSP00000452773	ENSP00000420714	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family	0.501
C15orf57	MRPS16	ENSP00000452773	ENSP00000362036	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family	0.501
C15orf57	MRPS18A	ENSP00000452773	ENSP00000361206	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily	0.404
C15orf57	MRPS18C	ENSP00000452773	ENSP00000295491	Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57	Mitochondrial ribosomal protein S18C	0.404
C18orf32	MRPS14	ENSP00000464411	ENSP00000420714	RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family	Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family	0.693
C18orf32	MRPS16	ENSP00000464411	ENSP00000362036	RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family	0.778
C18orf32	MRPS6	ENSP00000464411	ENSP00000382250	RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family	Mitochondrial ribosomal protein S6	0.798
C18orf32	MRPS9	ENSP00000464411	ENSP00000258455	RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family	Mitochondrial ribosomal protein S9	0.825
C18orf32	RPS29	ENSP00000464411	ENSP00000379339	RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family	Ribosomal protein S29	0.928
DAP3	MRPL22	ENSP00000357320	ENSP00000431040	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family	Mitochondrial ribosomal protein L22	0.980
DAP3	MRPL37	ENSP00000357320	ENSP00000354086	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family	Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family	0.995
DAP3	MRPL45	ENSP00000357320	ENSP00000484903	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family	Mitochondrial ribosomal protein L45	0.993
DAP3	MRPS14	ENSP00000357320	ENSP00000420714	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family	Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family	0.994
DAP3	MRPS16	ENSP00000357320	ENSP00000362036	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family	0.998

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