26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS12	Ribosomal protein S12 (132 aa)
	RPS16	Ribosomal protein S16 (146 aa)
	RPL8	60S ribosomal protein L8; Component of the large ribosomal subunit (257 aa)
	SRP14	Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (136 aa)
	RPS11	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family (158 aa)
	RPL37	60S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins (97 aa)
	RPS23	40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
	RPS9	Ribosomal protein S9 (194 aa)
	SRP9	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (86 aa)
	RPL15	Ribosomal protein L15 (204 aa)
	RPL38	Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family (70 aa)
	SRP68	Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (627 aa)
	RPS15A	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family (130 aa)
	RPS7	40S ribosomal protein S7; Required for rRNA maturation; Belongs to the eukaryotic ribosomal protein eS7 family (194 aa)
	RPS21	Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family (83 aa)
	RPL21	60S ribosomal protein L21; Component of the large ribosomal subunit (160 aa)
	RPS17	Ribosomal protein S17 (135 aa)
	RPS3A	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family (264 aa)
	RPL22	Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family (128 aa)
	RPS26	Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family (115 aa)
	RPL12	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA (165 aa)
	RPL39	Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family (51 aa)
	RPS27	40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family (84 aa)
	CDC5L	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing (802 aa)
	SRP19	Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (144 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (504 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC5L	RPL12	ENSP00000360532	ENSP00000354739	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	0.503
CDC5L	RPL22	ENSP00000360532	ENSP00000346088	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family	0.981
CDC5L	RPL39	ENSP00000360532	ENSP00000355315	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family	0.425
CDC5L	RPS16	ENSP00000360532	ENSP00000251453	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Ribosomal protein S16	0.507
CDC5L	SRP14	ENSP00000360532	ENSP00000267884	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding	0.452
CDC5L	SRP54	ENSP00000360532	ENSP00000451818	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)	0.981
CDC5L	SRP68	ENSP00000360532	ENSP00000312066	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function	0.980
RPL12	CDC5L	ENSP00000354739	ENSP00000360532	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	0.503
RPL12	RPL15	ENSP00000354739	ENSP00000309334	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein L15	0.999
RPL12	RPL21	ENSP00000354739	ENSP00000346027	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	60S ribosomal protein L21; Component of the large ribosomal subunit	0.999
RPL12	RPL22	ENSP00000354739	ENSP00000346088	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family	0.999
RPL12	RPL37	ENSP00000354739	ENSP00000274242	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	60S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins	0.999
RPL12	RPL38	ENSP00000354739	ENSP00000309830	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family	0.999
RPL12	RPL39	ENSP00000354739	ENSP00000355315	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family	0.999
RPL12	RPL8	ENSP00000354739	ENSP00000262584	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	60S ribosomal protein L8; Component of the large ribosomal subunit	0.999
RPL12	RPS11	ENSP00000354739	ENSP00000270625	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family	0.999
RPL12	RPS12	ENSP00000354739	ENSP00000230050	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein S12	0.999
RPL12	RPS15A	ENSP00000354739	ENSP00000318646	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family	0.999
RPL12	RPS16	ENSP00000354739	ENSP00000251453	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein S16	0.999
RPL12	RPS17	ENSP00000354739	ENSP00000346046	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	Ribosomal protein S17	0.999

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