• Version:
  • 11.0 [archived version]
STRINGSTRING
CDC5L CDC5L KRT71 KRT71 KRT1 KRT1 KRT83 KRT83 KRT82 KRT82 KRT79 KRT79 KRT85 KRT85 KRT7 KRT7 KRT6A KRT6A KRT84 KRT84 KRT39 KRT39 KRT4 KRT4 KRT5 KRT5 KRT23 KRT23 KRT26 KRT26 KRT18 KRT18 KRT72 KRT72 KRT78 KRT78 KRT6C KRT6C KRT76 KRT76 KRT6B KRT6B KRT73 KRT73 KRT81 KRT81 KRT77 KRT77 KRT75 KRT75 KRT74 KRT74
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT23Keratin, type I cytoskeletal 23; Keratins, type I (422 aa)
KRT5Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
KRT1Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
KRT75Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (551 aa)
KRT6CKeratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
KRT6BKeratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
KRT85Keratin, type II cuticular Hb5; Keratins, type II (507 aa)
KRT84Keratin, type II cuticular Hb4; Keratins, type II (600 aa)
KRT82Keratin, type II cuticular Hb2; Keratins, type II (513 aa)
KRT71Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (523 aa)
KRT83Keratin, type II cuticular Hb3; Keratins, type II (493 aa)
KRT72Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (511 aa)
KRT78Keratin, type II cytoskeletal 78; Keratins, type II (520 aa)
KRT73Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (540 aa)
KRT74Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II (529 aa)
KRT79Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family (535 aa)
KRT7Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7); Keratins, type II (469 aa)
KRT76Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II (638 aa)
KRT26Keratin, type I cytoskeletal 26; Keratins, type I; Belongs to the intermediate filament family (468 aa)
KRT77Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family (578 aa)
KRT39Keratin, type I cytoskeletal 39; May play a role in late hair differentiation; Belongs to the intermediate filament family (491 aa)
CDC5LCell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing (802 aa)
KRT6AKeratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair; Belongs to the intermediate filament family (564 aa)
KRT81Keratin, type II cuticular Hb1; Keratins, type II (505 aa)
KRT18Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection; Keratins, type I (430 aa)
KRT4Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family (520 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >