26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MRPS10	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family (201 aa)
	MRPS35	Mitochondrial ribosomal protein S35 (323 aa)
	MRPS7	Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family (242 aa)
	MRPL44	39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Mitochondrial ribosomal proteins (332 aa)
	MRPS9	Mitochondrial ribosomal protein S9 (396 aa)
	ACAT1	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism (427 aa)
	RPS11	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family (158 aa)
	ACAA2	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
	SNAP47	Synaptosomal-associated protein 47; Plays a role in intracellular membrane fusion (464 aa)
	HADHB	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta (474 aa)
	ACAA1	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 (424 aa)
	GGA1	ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (639 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (289 aa)
	ACAT2	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 (397 aa)
	DAP3	28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family (398 aa)
	TRAPPC3L	Trafficking protein particle complex subunit 3-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily (181 aa)
	MRPS16	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family (137 aa)
	PAICS	Multifunctional protein ADE2; Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily (432 aa)
	RMDN1	Regulator of microtubule dynamics 1 (314 aa)
	DROSHA	Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3’ and 5’ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Invo [...] (1374 aa)
	RPS20	Ribosomal protein S20 (142 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase; Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (307 aa)
	DICER1	Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3’ overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, a [...] (1922 aa)
	SOD2	Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (222 aa)
	RPS5	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family (204 aa)
	TRAPPC3	Trafficking protein particle complex subunit 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Trafficking protein particle complex (188 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAA2	ENSP00000333664	ENSP00000285093	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.843
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.932
ACAA1	ACAT2	ENSP00000333664	ENSP00000356015	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.919
ACAA1	ECHDC1	ENSP00000333664	ENSP00000436585	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Ethylmalonyl-CoA decarboxylase; Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level	0.878
ACAA1	HADHB	ENSP00000333664	ENSP00000325136	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.842
ACAA2	ACAA1	ENSP00000285093	ENSP00000333664	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.843
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.964
ACAA2	ACAT2	ENSP00000285093	ENSP00000356015	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.915
ACAA2	ECHDC1	ENSP00000285093	ENSP00000436585	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Ethylmalonyl-CoA decarboxylase; Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level	0.907
ACAA2	HADHB	ENSP00000285093	ENSP00000325136	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.925
ACAT1	ACAA1	ENSP00000265838	ENSP00000333664	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.932
ACAT1	ACAA2	ENSP00000265838	ENSP00000285093	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.964
ACAT1	ACAT2	ENSP00000265838	ENSP00000356015	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.947
ACAT1	ECHDC1	ENSP00000265838	ENSP00000436585	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	Ethylmalonyl-CoA decarboxylase; Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level	0.590
ACAT1	HADHB	ENSP00000265838	ENSP00000325136	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.940
ACAT2	ACAA1	ENSP00000356015	ENSP00000333664	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.919
ACAT2	ACAA2	ENSP00000356015	ENSP00000285093	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.915
ACAT2	ACAT1	ENSP00000356015	ENSP00000265838	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.947
ACAT2	ECHDC1	ENSP00000356015	ENSP00000436585	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Ethylmalonyl-CoA decarboxylase; Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level	0.574
ACAT2	HADHB	ENSP00000356015	ENSP00000325136	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.926

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