node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2 | CFB | ENSP00000299367 | ENSP00000416561 | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | 0.921 |
C2 | CFI | ENSP00000299367 | ENSP00000378130 | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family | 0.959 |
C2 | MASP1 | ENSP00000299367 | ENSP00000296280 | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family | Mannan binding lectin serine peptidase 1 | 0.941 |
CFB | C2 | ENSP00000416561 | ENSP00000299367 | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family | 0.921 |
CFB | CFD | ENSP00000416561 | ENSP00000332139 | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family | 0.992 |
CFB | CFI | ENSP00000416561 | ENSP00000378130 | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family | 0.983 |
CFB | ENSG00000244255 | ENSP00000416561 | ENSP00000410815 | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family | 0.800 |
CFB | GZMM | ENSP00000416561 | ENSP00000264553 | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | Granzyme M; Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells | 0.901 |
CFD | CFB | ENSP00000332139 | ENSP00000416561 | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | 0.992 |
CFD | ENSG00000244255 | ENSP00000332139 | ENSP00000410815 | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family | 0.926 |
CFI | C2 | ENSP00000378130 | ENSP00000299367 | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family | 0.959 |
CFI | CFB | ENSP00000378130 | ENSP00000416561 | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | 0.983 |
CFI | ENSG00000244255 | ENSP00000378130 | ENSP00000410815 | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family | 0.717 |
ENSG00000244255 | CFB | ENSP00000410815 | ENSP00000416561 | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | 0.800 |
ENSG00000244255 | CFD | ENSP00000410815 | ENSP00000332139 | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway; Belongs to the peptidase S1 family | 0.926 |
ENSG00000244255 | CFI | ENSP00000410815 | ENSP00000378130 | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family | 0.717 |
F2 | PROC | ENSP00000308541 | ENSP00000234071 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family | Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function; Belongs to the peptidase S1 family | 0.996 |
GZMM | CFB | ENSP00000264553 | ENSP00000416561 | Granzyme M; Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes; Belongs to the peptidase S1 family | 0.901 |
MASP1 | C2 | ENSP00000296280 | ENSP00000299367 | Mannan binding lectin serine peptidase 1 | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family | 0.941 |
PHACTR3 | TMPRSS11B | ENSP00000360054 | ENSP00000330475 | Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators | Transmembrane protease serine 11B; Serine protease | 0.430 |