node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAIAP2 | C19orf25 | ENSP00000316338 | ENSP00000397394 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | 0.723 |
BAIAP2 | EPS8 | ENSP00000316338 | ENSP00000281172 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] | 0.986 |
C19orf25 | BAIAP2 | ENSP00000397394 | ENSP00000316338 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | 0.723 |
C19orf25 | RINT1 | ENSP00000397394 | ENSP00000257700 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | 0.969 |
C19orf25 | SCFD2 | ENSP00000397394 | ENSP00000384182 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Sec1 family domain-containing protein 2; May be involved in protein transport | 0.865 |
C19orf25 | SEC22B | ENSP00000397394 | ENSP00000463393 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family | 0.646 |
C19orf25 | USE1 | ENSP00000397394 | ENSP00000263897 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs | 0.727 |
C19orf25 | ZW10 | ENSP00000397394 | ENSP00000200135 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assemb [...] | 0.503 |
EPS8 | BAIAP2 | ENSP00000281172 | ENSP00000316338 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | 0.986 |
F2RL1 | USE1 | ENSP00000296677 | ENSP00000263897 | Proteinase-activated receptor 2; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergisticall [...] | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs | 0.619 |
RINT1 | C19orf25 | ENSP00000257700 | ENSP00000397394 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | 0.969 |
RINT1 | SCFD2 | ENSP00000257700 | ENSP00000384182 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | Sec1 family domain-containing protein 2; May be involved in protein transport | 0.960 |
RINT1 | SEC22B | ENSP00000257700 | ENSP00000463393 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family | 0.991 |
RINT1 | USE1 | ENSP00000257700 | ENSP00000263897 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs | 0.998 |
RINT1 | ZW10 | ENSP00000257700 | ENSP00000200135 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assemb [...] | 0.999 |
SCFD2 | C19orf25 | ENSP00000384182 | ENSP00000397394 | Sec1 family domain-containing protein 2; May be involved in protein transport | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | 0.865 |
SCFD2 | RINT1 | ENSP00000384182 | ENSP00000257700 | Sec1 family domain-containing protein 2; May be involved in protein transport | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control; Belongs to the RINT1 family | 0.960 |
SCFD2 | SEC22B | ENSP00000384182 | ENSP00000463393 | Sec1 family domain-containing protein 2; May be involved in protein transport | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family | 0.834 |
SCFD2 | USE1 | ENSP00000384182 | ENSP00000263897 | Sec1 family domain-containing protein 2; May be involved in protein transport | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs | 0.888 |
SCFD2 | ZW10 | ENSP00000384182 | ENSP00000200135 | Sec1 family domain-containing protein 2; May be involved in protein transport | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assemb [...] | 0.942 |