• Version:
  • 11.0 [archived version]
STRINGSTRING
EXOC3L2 EXOC3L2 ZNF408 ZNF408 PRDM5 PRDM5 EBF4 EBF4 PRDM14 PRDM14 EBF2 EBF2 PRDM7 PRDM7 PRDM4 PRDM4 ZNF10 ZNF10 EBF3 EBF3 ZNF773 ZNF773 ZNF629 ZNF629 KCNC1 KCNC1 EBF1 EBF1 FOXF1 FOXF1 ZBTB24 ZBTB24 ZNF862 ZNF862 ZNF84 ZNF84 ZNF777 ZNF777 ZNF221 ZNF221 ZNF436 ZNF436 MEIS1 MEIS1 PRDM15 PRDM15 MYNN MYNN ZNF500 ZNF500 MECOM MECOM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF500Zinc finger protein 500; May be involved in transcriptional regulation; SCAN domain containing (480 aa)
ZNF862Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1169 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily (801 aa)
ZBTB24Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription; BTB domain containing (697 aa)
ZNF777Zinc finger protein 777; May be involved in transcriptional regulation; Zinc fingers C2H2-type (831 aa)
ZNF10Zinc finger protein 10; May be involved in transcriptional regulation; Zinc fingers C2H2-type (573 aa)
ZNF221Zinc finger protein 221; May be involved in transcriptional regulation; Zinc fingers C2H2-type (617 aa)
FOXF1Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes; Forkhead boxes (379 aa)
ZNF629Zinc finger protein 629; May be involved in transcriptional regulation; Zinc fingers C2H2-type (869 aa)
MECOMMDS1 and EVI1 complex locus protein EVI1; Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis; Lysine methyltransferases (1116 aa)
PRDM5PR domain zinc finger protein 5; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. Ma [...] (630 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action [...] (585 aa)
PRDM15PR domain zinc finger protein 15; May be involved in transcriptional regulation; PR/SET domain family (1507 aa)
MEIS1Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias; TALE class homeoboxes and pseudogenes (390 aa)
PRDM14PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels- the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the exp [...] (571 aa)
ZNF773Zinc finger protein 773; May be involved in transcriptional regulation; Zinc fingers C2H2-type (442 aa)
ZNF408Zinc finger protein 408; May be involved in transcriptional regulation; PR/SET domain family (720 aa)
ZNF436Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family (470 aa)
EBF1Transcription factor COE1; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (591 aa)
MYNNMyoneurin; Zinc fingers C2H2-type; BTB domain containing (610 aa)
ZNF84Zinc finger protein 84; May be involved in transcriptional regulation; Zinc fingers C2H2-type (738 aa)
EBF3Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity); Belongs to the COE family (551 aa)
EBF4Transcription factor COE4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’; Belongs to the COE family (598 aa)
PRDM7Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family (492 aa)
EXOC3L2Exocyst complex component 3-like protein 2; Armadillo-like helical domain containing; Belongs to the SEC6 family (409 aa)
EBF2Transcription factor COE2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (575 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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