• Version:
  • 11.0 [archived version]
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MYH7B MYH7B MYH15 MYH15 TPM1 TPM1 TMOD4 TMOD4 MYH1 MYH1 TPM2 TPM2 MYH14 MYH14 TMOD2 TMOD2 MYBPC2 MYBPC2 MYH11 MYH11 MYH2 MYH2 MYH6 MYH6 TCAP TCAP MYBPH MYBPH MYH8 MYH8 TMOD3 TMOD3 TNNI1 TNNI1 MYH13 MYH13 MYOM2 MYOM2 MYH3 MYH3 MYH7 MYH7 MYH9 MYH9 TMOD1 TMOD1 ACTN2 ACTN2 MYH4 MYH4 MYBPHL MYBPHL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10; Deafness associated genes (1960 aa)
MYH1Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1939 aa)
MYH2Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity); Myosin heavy chains (1941 aa)
TMOD2Tropomodulin-2; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Tropomodulins (351 aa)
MYH4Myosin-4; Muscle contraction; Myosin heavy chains (1939 aa)
MYBPHMyosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing (477 aa)
TMOD1Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus; Tropomodulins (359 aa)
MYOM2Myomesin-2; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent; Fibronectin type III domain containing (1465 aa)
MYH7BMyosin-7B; Involved in muscle contraction; Myosin heavy chains (1983 aa)
MYH15Myosin-15; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1946 aa)
TMOD4Tropomodulin-4; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton; Tropomodulins (345 aa)
TMOD3Tropomodulin-3; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Belongs to the tropomodulin family (352 aa)
TCAPTelethonin; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (167 aa)
MYH7Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1935 aa)
MYBPHLMyosin-binding protein H-like; Fibronectin type III domain containing; Belongs to the immunoglobulin superfamily. MyBP family (354 aa)
MYBPC2Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Fibronectin type III domain containing (1141 aa)
TPM1Tropomyosin alpha-1 chain; Tropomyosin 1; Tropomyosins (284 aa)
TNNI1Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (187 aa)
TPM2Tropomyosin beta chain; Tropomyosin 2; Belongs to the tropomyosin family (284 aa)
MYH11Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1979 aa)
MYH8Myosin-8; Muscle contraction; Myosin heavy chains (1937 aa)
MYH6Myosin-6; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1939 aa)
MYH13Myosin-13; Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles; Myosin heavy chains (1938 aa)
ACTN2Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins (894 aa)
MYH3Myosin-3; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1940 aa)
MYH14Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes (2036 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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