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  • 11.0 [archived version]
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TBX20 TBX20 DTNA DTNA TEKT4 TEKT4 TEKT5 TEKT5 TBX10 TBX10 PPP1R21 PPP1R21 TBX15 TBX15 TBX1 TBX1 DTNB DTNB SOX8 SOX8 HMX1 HMX1 SOX9 SOX9 TEKT1 TEKT1 VSX2 VSX2 HINFP HINFP SOX30 SOX30 TBX22 TBX22 SOX4 SOX4 MAFIP MAFIP ISY1-RAB43 ISY1-RAB43 TEKT3 TEKT3 FAM46B FAM46B ISY1 ISY1 TBX18 TBX18 TEKT2 TEKT2 ENSG00000274847 ENSG00000274847
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX15T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity); T-boxes (496 aa)
TEKT2Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Tektins (430 aa)
SOX4Transcription factor SOX-4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif; SRY-boxes (474 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Important for normal skeletal development; SRY-boxes (509 aa)
VSX2Visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family (361 aa)
SOX30Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes (753 aa)
ISY1Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing; Spliceosomal B complex (307 aa)
TEKT5Tektin-5; May be a structural component of the sperm flagellum; Tektins (485 aa)
FAM46BPutative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase (425 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5’-[AT][AT]CAA[AT]G-3’ (By similarity); SRY-boxes (446 aa)
PPP1R21Protein phosphatase 1 regulatory subunit 21 (780 aa)
TEKT4Tektin-4; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity); Tektins (435 aa)
HINFPHistone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter; Zinc fingers C2H2-type (517 aa)
TBX1T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity); T-boxes (495 aa)
TBX10T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes; T-boxes (385 aa)
TEKT1Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family (418 aa)
TBX18T-box transcription factor TBX18; Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area; T-boxes (607 aa)
TBX22T-box transcription factor TBX22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis; T-boxes (520 aa)
TEKT3Tektin-3; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity); Tektins (490 aa)
HMX1Homeobox protein HMX1; DNA-binding protein that binds to the 5’-CAAG-3’ core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear; NKL subclass homeoboxes and pseudogenes (348 aa)
DTNBDystrobrevin beta; Zinc fingers ZZ-type; Belongs to the dystrophin family. Dystrobrevin subfamily (627 aa)
TBX20T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart; T-boxes (447 aa)
ISY1-RAB43Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing (331 aa)
DTNADystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. Dystrobrevin subfamily (724 aa)
ENSG00000274847annotation not available (129 aa)
MAFIPMaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency; Belongs to the tektin family (124 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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