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  • 11.0 [archived version]
STRINGSTRING
SMCP SMCP KRTAP9-3 KRTAP9-3 KRTAP9-2 KRTAP9-2 RGS17 RGS17 LCE3A LCE3A KRTAP5-9 KRTAP5-9 LCE1D LCE1D LCE1F LCE1F FUCA2 FUCA2 LCE1C LCE1C LELP1 LELP1 KRTAP4-2 KRTAP4-2 NUFIP2 NUFIP2 LCE1B LCE1B LCE1A LCE1A LCE4A LCE4A LCE5A LCE5A KRTAP1-5 KRTAP1-5 NR4A3 NR4A3 LCE3C LCE3C LCE3D LCE3D LCE2C LCE2C LCE3E LCE3E KRTAP5-3 KRTAP5-3 CRCT1 CRCT1 RAMP3 RAMP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FUCA2Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family (467 aa)
NUFIP2Nuclear fragile X mental retardation-interacting protein 2; Binds RNA (695 aa)
RAMP3Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL; Receptor activity modifying proteins (148 aa)
LCE1DLate cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum (114 aa)
LCE5ALate cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (118 aa)
LCE1FLate cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE3CLate cornified envelope protein 3C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (94 aa)
LCE1ALate cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE3ALate cornified envelope protein 3A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (89 aa)
LCE1BLate cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum (118 aa)
KRTAP1-5Keratin-associated protein 1-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 1 family (174 aa)
RGS17Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) (210 aa)
LELP1Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family (98 aa)
SMCPSperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) (116 aa)
LCE4ALate cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (99 aa)
LCE2CLate cornified envelope protein 2C; Precursors of the cornified envelope of the stratum (110 aa)
LCE3DLate cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (92 aa)
LCE3ELate cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum (92 aa)
CRCT1Cysteine rich C-terminal 1 (99 aa)
KRTAP9-2Keratin-associated protein 9-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (174 aa)
KRTAP4-2Keratin-associated protein 4-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (136 aa)
KRTAP5-3Keratin-associated protein 5-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family (238 aa)
KRTAP9-3Keratin-associated protein 9-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (159 aa)
KRTAP5-9Keratin-associated protein 5-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (169 aa)
LCE1CLate cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum (118 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3; Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5’-AAAAGGTCA-3’ site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vasc [...] (637 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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