26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MRPS10	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family (201 aa)
	MRPL32	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family (188 aa)
	MRPL27	Mitochondrial ribosomal protein L27 (148 aa)
	MRPS7	Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family (242 aa)
	MRPL34	Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family (92 aa)
	MRPS9	Mitochondrial ribosomal protein S9 (396 aa)
	MRPL15	Mitochondrial ribosomal protein L15 (296 aa)
	MRPS5	Mitochondrial ribosomal protein S5 (430 aa)
	MRPL17	Mitochondrial ribosomal protein L17 (175 aa)
	MRPL33	Mitochondrial ribosomal protein L33 (65 aa)
	ICT1	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
	MRPL13	Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family (178 aa)
	MRPL11	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family (192 aa)
	MRPL43	Mitochondrial ribosomal protein L43 (235 aa)
	MRPL20	Mitochondrial ribosomal protein L20 (149 aa)
	MRPL21	Mitochondrial ribosomal protein L21 (205 aa)
	MRPL9	Mitochondrial ribosomal protein L9 (267 aa)
	MRPL41	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
	MRPS2	Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family (296 aa)
	MRPS16	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family (137 aa)
	MRPS15	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family (257 aa)
	MRPL19	Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family (292 aa)
	MRPS6	Mitochondrial ribosomal protein S6 (125 aa)
	MRPS12	Mitochondrial ribosomal protein S12 (138 aa)
	MRPS14	Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family (128 aa)
	MRPL36	Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family (103 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ICT1	MRPL11	ENSP00000301585	ENSP00000308897	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family	0.997
ICT1	MRPL13	ENSP00000301585	ENSP00000306548	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family	0.998
ICT1	MRPL15	ENSP00000301585	ENSP00000260102	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L15	0.995
ICT1	MRPL17	ENSP00000301585	ENSP00000288937	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L17	0.997
ICT1	MRPL19	ENSP00000301585	ENSP00000377486	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family	0.999
ICT1	MRPL20	ENSP00000301585	ENSP00000341082	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L20	0.998
ICT1	MRPL21	ENSP00000301585	ENSP00000354580	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L21	0.998
ICT1	MRPL27	ENSP00000301585	ENSP00000225969	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L27	0.997
ICT1	MRPL32	ENSP00000301585	ENSP00000223324	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family	0.996
ICT1	MRPL33	ENSP00000301585	ENSP00000296102	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L33	0.997
ICT1	MRPL34	ENSP00000301585	ENSP00000252602	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family	0.987
ICT1	MRPL36	ENSP00000301585	ENSP00000423399	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family	0.997
ICT1	MRPL41	ENSP00000301585	ENSP00000360498	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins	0.998
ICT1	MRPL43	ENSP00000301585	ENSP00000339844	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L43	0.986
ICT1	MRPL9	ENSP00000301585	ENSP00000357823	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein L9	0.996
ICT1	MRPS10	ENSP00000301585	ENSP00000053468	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family	0.996
ICT1	MRPS12	ENSP00000301585	ENSP00000384952	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein S12	0.994
ICT1	MRPS14	ENSP00000301585	ENSP00000420714	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family	0.994
ICT1	MRPS15	ENSP00000301585	ENSP00000362208	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family	0.995
ICT1	MRPS16	ENSP00000301585	ENSP00000362036	Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family	0.998

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