• Version:
  • 11.0 [archived version]
STRINGSTRING
TOP1 TOP1 ZNF512 ZNF512 STAU1 STAU1 RPL37A RPL37A ZC3HAV1 ZC3HAV1 NOL12 NOL12 RBM34 RBM34 RPL14 RPL14 ENSG00000243207 ENSG00000243207 RPL18A RPL18A RBM28 RBM28 RPL32 RPL32 TOP1MT TOP1MT SURF6 SURF6 BRIX1 BRIX1 NIFK NIFK BOP1 BOP1 GTPBP4 GTPBP4 RSL1D1 RSL1D1 PES1 PES1 RPF1 RPF1 MAK16 MAK16 DDX18 DDX18 RRP15 RRP15 EIF6 EIF6 WDR74 WDR74
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL18ARibosomal protein L18a (176 aa)
RBM28RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes; RNA binding motif containing (759 aa)
ZC3HAV1Zinc finger CCCH-type antiviral protein 1; Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3’- 5’ exoribonuclease complex exosome to degrade the RNA body from the 3’-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from t [...] (902 aa)
DDX18ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily (670 aa)
NIFKNucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing (293 aa)
TOP1MTDNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, [...] (601 aa)
BRIX1Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit (353 aa)
PES1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family (588 aa)
ZNF512Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type (567 aa)
NOL12Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family (213 aa)
MAK16Protein MAK16 homolog; RNA binding motif containing (300 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily (634 aa)
TOP1DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remov [...] (765 aa)
RRP15RRP15-like protein; Ribosomal RNA processing 15 homolog (282 aa)
RPF1Ribosome production factor 1; May be required for ribosome biogenesis (349 aa)
STAU1Double-stranded RNA-binding protein Staufen homolog 1; Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site; Protein phosphatase 1 regulatory subunits (577 aa)
SURF6Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) (361 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] (245 aa)
ENSG00000243207PPAN-P2RY11 readthrough; Belongs to the G-protein coupled receptor 1 family (794 aa)
RPL1460S ribosomal protein L14; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL14 family (215 aa)
RBM34RNA-binding protein 34; RNA binding motif containing; Belongs to the RRM RBM34 family (430 aa)
RPL32Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family (135 aa)
RPL37ARibosomal protein L37a (92 aa)
WDR74WD repeat-containing protein 74; WD repeat domain containing (385 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family (746 aa)
RSL1D1Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent (490 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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