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STRINGSTRING
VRK1 VRK1 GOLGA8O GOLGA8O ERGIC1 ERGIC1 GOLGA8T GOLGA8T GOLGA8A GOLGA8A GOLGA8K GOLGA8K GOLGA8B GOLGA8B ACBD3 ACBD3 GOLGA8N GOLGA8N GOLGA6D GOLGA6D GOLGA6A GOLGA6A GOLGB1 GOLGB1 GOLGA8R GOLGA8R USO1 USO1 GOSR1 GOSR1 STX5 STX5 GOLGA8S GOLGA8S GOLGA6B GOLGA6B GOLGA2 GOLGA2 RAB1A RAB1A GOLGA8F GOLGA8F GOLGA8H GOLGA8H GOLGA6L2 GOLGA6L2 GOLGA8J GOLGA8J GOLGA6C GOLGA6C GOLGA8M GOLGA8M
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VRK1Serine/threonine-protein kinase VRK1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle- following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates ’Thr- 18’ of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1- disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosph [...] (396 aa)
GOSR1Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] (250 aa)
GOLGA6AGolgin A6 family member A; Belongs to the GOLGA6 family (693 aa)
STX5Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus; Syntaxins (355 aa)
GOLGA6CGolgin A6 family member C; Belongs to the GOLGA6 family (693 aa)
GOLGA8RGolgin A8 family member R (631 aa)
GOLGA8BGolgin subfamily A member 8B; May be involved in maintaining Golgi structure; Belongs to the GOLGA8 family (603 aa)
GOLGA8AGolgin subfamily A member 8A; May be involved in maintaining Golgi structure (603 aa)
ACBD3Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins (528 aa)
GOLGB1Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex (3269 aa)
ERGIC1Endoplasmic reticulum-Golgi intermediate compartment protein 1; Possible role in transport between endoplasmic reticulum and Golgi (290 aa)
RAB1ARas-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...] (205 aa)
GOLGA6DGolgin A6 family member D; Belongs to the GOLGA6 family (693 aa)
GOLGA8NGolgin A8 family member N; Belongs to the GOLGA8 family (632 aa)
GOLGA6BGolgin A6 family member B; Belongs to the GOLGA6 family (693 aa)
GOLGA2Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly- phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing teth [...] (1002 aa)
GOLGA8OGolgin A8 family member O; Belongs to the GOLGA6 family (632 aa)
GOLGA8KGolgin A8 family member K; Belongs to the GOLGA8 family (630 aa)
USO1General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Armadillo-like helical domain containing (962 aa)
GOLGA8FGolgin A8 family member F; Belongs to the GOLGA8 family (648 aa)
GOLGA6L2Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family (909 aa)
GOLGA8SGolgin A8 family member S (625 aa)
GOLGA8TGolgin A8 family member T (631 aa)
GOLGA8JGolgin A8 family member J; Belongs to the GOLGA8 family (632 aa)
GOLGA8HGolgin A8 family member H; Belongs to the GOLGA8 family (632 aa)
GOLGA8MGolgin A8 family member M (632 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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