• Version:
  • 11.0 [archived version]
STRINGSTRING
ZIC1 ZIC1 ZIC4 ZIC4 ZSCAN30 ZSCAN30 ZNF507 ZNF507 ADD3 ADD3 ENSG00000197054 ENSG00000197054 ZNF235 ZNF235 ZNF612 ZNF612 ADD1 ADD1 ADD2 ADD2 RASGEF1C RASGEF1C ZNF25 ZNF25 ZNF624 ZNF624 SH3GL2 SH3GL2 EPS15L1 EPS15L1 S100A7A S100A7A ZNF248 ZNF248 ZBTB26 ZBTB26 EPS15 EPS15 SYNRG SYNRG ZNF359 ZNF359 ZNF536 ZNF536 MZF1 MZF1 ZSCAN1 ZSCAN1 NR2C1 NR2C1 ZNF512 ZNF512
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MZF1Myeloid zinc finger 1; Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development; Belongs to the krueppel C2H2-type zinc-finger protein family (734 aa)
ADD2Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit; Belongs to the aldolase class II family. Adducin subfamily (726 aa)
ADD1Alpha-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin (768 aa)
ZSCAN1Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing (408 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplas [...] (447 aa)
ZNF235Zinc finger protein 235; May be involved in transcriptional regulation; Zinc fingers C2H2-type (738 aa)
ZNF25Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type (456 aa)
ZNF624Zinc finger protein 624; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (865 aa)
ZNF507Zinc finger protein 507; May be involved in transcriptional regulation; Zinc fingers C2H2-type (953 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] (603 aa)
ZNF512Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type (567 aa)
ZNF536Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’; Zinc fingers C2H2-type (1300 aa)
ADD3Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily (706 aa)
S100A7AProtein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing (101 aa)
EPS15Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internali [...] (896 aa)
ZBTB26Zinc finger and BTB domain-containing protein 26; May be involved in transcriptional regulation; BTB domain containing (441 aa)
SH3GL2Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes; N-BAR domain containing (352 aa)
RASGEF1CRas-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) (466 aa)
ZNF359Zinc finger protein 23; May be involved in transcriptional regulation. May have a role in embryonic development; Belongs to the krueppel C2H2-type zinc-finger protein family (643 aa)
ZNF248Zinc finger protein 248; May be involved in transcriptional regulation; Zinc fingers C2H2-type (579 aa)
ZNF612Zinc finger protein 23; May be involved in transcriptional regulation. May have a role in embryonic development; Belongs to the krueppel C2H2-type zinc-finger protein family (643 aa)
ZSCAN30Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation; SCAN domain containing (494 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2; EF-hand domain containing (910 aa)
ZIC4Zinc finger protein ZIC 4; Binds to DNA; Zinc fingers C2H2-type (384 aa)
ENSG00000197054Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type (414 aa)
SYNRGSynergin gamma; May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins (1314 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]