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  • 11.0 [archived version]
STRINGSTRING
YBEY YBEY RPL10A RPL10A IMPDH1 IMPDH1 RPL3L RPL3L SRPR SRPR RPL9 RPL9 RPL23A RPL23A RPLP0 RPLP0 HDDC3 HDDC3 RPL3 RPL3 MRTO4 MRTO4 GTPBP8 GTPBP8 MRPL21 MRPL21 MRPL27 MRPL27 MRPS6 MRPS6 ENSG00000262660 ENSG00000262660 MRPL12 MRPL12 MRPL3 MRPL3 MALSU1 MALSU1 ERGIC1 ERGIC1 MRPL1 MRPL1 AMIGO3 AMIGO3 CDC23 CDC23 ERGIC3 ERGIC3 HSPD1 HSPD1 ERGIC2 ERGIC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRPL27Mitochondrial ribosomal protein L27 (148 aa)
MRPL3Mitochondrial ribosomal protein L3 (348 aa)
RPL3LRibosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family (407 aa)
MRPL1Mitochondrial ribosomal protein L1 (325 aa)
AMIGO3Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity); Immunoglobulin like domain containing (504 aa)
SRPRSignal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (638 aa)
YBEYEndoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation (167 aa)
MRPL1239S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family (198 aa)
IMPDH1Inosine-5’-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors; Belongs to the IMPDH/GMPR family (599 aa)
RPL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins (403 aa)
ERGIC3Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family (388 aa)
ERGIC2Endoplasmic reticulum-Golgi intermediate compartment protein 2; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family (377 aa)
MRPL21Mitochondrial ribosomal protein L21 (205 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit (217 aa)
MRTO4mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes (239 aa)
GTPBP8GTP binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family (284 aa)
HSPD160 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
ERGIC1Endoplasmic reticulum-Golgi intermediate compartment protein 1; Possible role in transport between endoplasmic reticulum and Golgi (290 aa)
HDDC3Guanosine-3’,5’-bis(diphosphate) 3’-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response (179 aa)
CDC23Cell division cycle protein 23 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC8/CDC23 family (597 aa)
MRPS6Mitochondrial ribosomal protein S6 (125 aa)
RPL23A60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family (156 aa)
RPL9L ribosomal proteins (192 aa)
MALSU1Mitochondrial assembly of ribosomal large subunit protein 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome; Belongs to the Iojap/RsfS family (234 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (317 aa)
ENSG00000262660Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane (442 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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