• Version:
  • 11.0 [archived version]
STRINGSTRING
DEFA4 DEFA4 DEFA5 DEFA5 DEFA3 DEFA3 DEFB134 DEFB134 DEFB108B DEFB108B DEFB128 DEFB128 DEFB124 DEFB124 DEFB136 DEFB136 DEFB135 DEFB135 DEFB118 DEFB118 DEFB113 DEFB113 DEFB129 DEFB129 DEFB125 DEFB125 DEFB131 DEFB131 DEFB112 DEFB112 DEFB110 DEFB110 DEFB114 DEFB114 DEFB127 DEFB127 DEFB123 DEFB123 DEFB126 DEFB126 DEFB116 DEFB116 DEFB132 DEFB132 DEFB115 DEFB115 DEFB1 DEFB1 DEFB119 DEFB119 DEFB121 DEFB121
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEFB129Beta-defensin 129; Has antibacterial activity; Defensins, beta (183 aa)
DEFB118Beta-defensin 118; Has antibacterial activity; Defensins, beta (123 aa)
DEFA4Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production; Defensins, alpha (97 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family (68 aa)
DEFB114Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS- induced reduction of sperm motility in vitro and may protect from LPS-induced lethality; Defensins, beta (69 aa)
DEFB112Beta-defensin 112; Has antibacterial activity; Defensins, beta (113 aa)
DEFB124Beta-defensin 124; Has antibacterial activity; Defensins, beta (71 aa)
DEFA3Neutrophil defensin 3; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane; Defensins, alpha (94 aa)
DEFA5Defensin-5; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing; Defensins, alpha (94 aa)
DEFB108BBeta-defensin 108B; Has antibacterial activity; Defensins, beta (73 aa)
DEFB128Beta-defensin 128; Has antibacterial activity; Defensins, beta (93 aa)
DEFB131Beta-defensin 131A; Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion; Belongs to the beta-defensin family (70 aa)
DEFB110Beta-defensin 110; Has antibacterial activity; Defensins, beta (67 aa)
DEFB123Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family (67 aa)
DEFB119Defensin beta 119 (88 aa)
DEFB135Beta-defensin 135; Has antibacterial activity; Defensins, beta (77 aa)
DEFB136Beta-defensin 136; Has antibacterial activity; Defensins, beta (78 aa)
DEFB132Beta-defensin 132; Has antibacterial activity; Defensins, beta (95 aa)
DEFB127Beta-defensin 127; Has antibacterial activity; Defensins, beta (99 aa)
DEFB126Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] (111 aa)
DEFB125Beta-defensin 125; Has antibacterial activity; Defensins, beta (156 aa)
DEFB113Beta-defensin 113; Has antibacterial activity; Defensins, beta (82 aa)
DEFB116Beta-defensin 116; Has antibacterial activity; Defensins, beta (102 aa)
DEFB115Beta-defensin 115; Has antibacterial activity; Defensins, beta (88 aa)
DEFB121Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family (76 aa)
DEFB134Beta-defensin 134; Has antibacterial activity; Defensins, beta (66 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]