| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GID8 | MAEA | ENSP00000266069 | ENSP00000302830 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.720 |
| GID8 | RANBP10 | ENSP00000266069 | ENSP00000316589 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.911 |
| GID8 | RMND5A | ENSP00000266069 | ENSP00000283632 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.988 |
| GID8 | WDR26 | ENSP00000266069 | ENSP00000408108 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.975 |
| INSL6 | RMND5A | ENSP00000371054 | ENSP00000283632 | Insulin-like peptide INSL6; May have a role in sperm development and fertilization | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.672 |
| INSL6 | WBP5 | ENSP00000371054 | ENSP00000361745 | Insulin-like peptide INSL6; May have a role in sperm development and fertilization | Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation | 0.672 |
| MAEA | GID8 | ENSP00000302830 | ENSP00000266069 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.720 |
| MAEA | RANBP10 | ENSP00000302830 | ENSP00000316589 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.740 |
| MAEA | RMND5A | ENSP00000302830 | ENSP00000283632 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.986 |
| MAEA | WDR26 | ENSP00000302830 | ENSP00000408108 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.955 |
| RANBP10 | GID8 | ENSP00000316589 | ENSP00000266069 | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.911 |
| RANBP10 | MAEA | ENSP00000316589 | ENSP00000302830 | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.740 |
| RANBP10 | RMND5A | ENSP00000316589 | ENSP00000283632 | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.968 |
| RANBP10 | WDR26 | ENSP00000316589 | ENSP00000408108 | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.951 |
| RMND5A | GID8 | ENSP00000283632 | ENSP00000266069 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.988 |
| RMND5A | INSL6 | ENSP00000283632 | ENSP00000371054 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | Insulin-like peptide INSL6; May have a role in sperm development and fertilization | 0.672 |
| RMND5A | MAEA | ENSP00000283632 | ENSP00000302830 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division eve [...] | 0.986 |
| RMND5A | RANBP10 | ENSP00000283632 | ENSP00000316589 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.968 |
| RMND5A | WBP5 | ENSP00000283632 | ENSP00000361745 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation | 0.752 |
| RMND5A | WDR26 | ENSP00000283632 | ENSP00000408108 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.984 |
