node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF15 | C11orf49 | ENSP00000355026 | ENSP00000367878 | Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2; Rho guanine nucleotide exchange factors | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.480 |
C11orf49 | ARHGEF15 | ENSP00000367878 | ENSP00000355026 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2; Rho guanine nucleotide exchange factors | 0.480 |
C11orf49 | EIF3F | ENSP00000367878 | ENSP00000431800 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.552 |
C11orf49 | LRRC49 | ENSP00000367878 | ENSP00000453273 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.914 |
C11orf49 | NICN1 | ENSP00000367878 | ENSP00000273598 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Nicolin-1; Nicolin 1 | 0.835 |
C11orf49 | TPGS2 | ENSP00000367878 | ENSP00000464780 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Tubulin polyglutamylase complex subunit 2 | 0.857 |
C11orf49 | TTLL1 | ENSP00000367878 | ENSP00000266254 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.822 |
EIF3F | C11orf49 | ENSP00000431800 | ENSP00000367878 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.552 |
EIF3F | LRRC49 | ENSP00000431800 | ENSP00000453273 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.732 |
EIF3F | RPL8 | ENSP00000431800 | ENSP00000262584 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 60S ribosomal protein L8; Component of the large ribosomal subunit | 0.985 |
LRRC49 | C11orf49 | ENSP00000453273 | ENSP00000367878 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.914 |
LRRC49 | EIF3F | ENSP00000453273 | ENSP00000431800 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.732 |
LRRC49 | NICN1 | ENSP00000453273 | ENSP00000273598 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Nicolin-1; Nicolin 1 | 0.982 |
LRRC49 | TPGS2 | ENSP00000453273 | ENSP00000464780 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Tubulin polyglutamylase complex subunit 2 | 0.981 |
LRRC49 | TTLL1 | ENSP00000453273 | ENSP00000266254 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.983 |
NICN1 | C11orf49 | ENSP00000273598 | ENSP00000367878 | Nicolin-1; Nicolin 1 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family | 0.835 |
NICN1 | LRRC49 | ENSP00000273598 | ENSP00000453273 | Nicolin-1; Nicolin 1 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 | 0.982 |
NICN1 | TPGS2 | ENSP00000273598 | ENSP00000464780 | Nicolin-1; Nicolin 1 | Tubulin polyglutamylase complex subunit 2 | 0.986 |
NICN1 | TTLL1 | ENSP00000273598 | ENSP00000266254 | Nicolin-1; Nicolin 1 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.986 |
RAB17 | RAB29 | ENSP00000264601 | ENSP00000356107 | Ras-related protein Rab-17; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in [...] | Ras-related protein Rab-7L1; Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epit [...] | 0.914 |