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  • 11.0 [archived version]
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CMTM4 CMTM4 CMTM3 CMTM3 CMTM2 CMTM2 CMTM8 CMTM8 CMTM5 CMTM5 PLP2 PLP2 CMTM1 CMTM1 ACBD3 ACBD3 CKLF CKLF SLC2A5 SLC2A5 CMTM6 CMTM6 CMTM7 CMTM7 TMEM35 TMEM35 TMED8 TMED8 SLC28A3 SLC28A3 SLC2A1 SLC2A1 PLLP PLLP MYADML2 MYADML2 SLC2A2 SLC2A2 MAL MAL MYADM MYADM ZMYM6NB ZMYM6NB SLC22A18 SLC22A18 CKLF-CMTM1 CKLF-CMTM1 MARVELD1 MARVELD1 MAL2 MAL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CMTM6CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family (183 aa)
TMED8Protein TMED8; Transmembrane p24 trafficking protein family member 8; GOLD domain containing (325 aa)
PLLPPlasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family (182 aa)
CKLFChemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa)
CMTM2CKLF like MARVEL transmembrane domain containing 2; Belongs to the chemokine-like factor family (248 aa)
CMTM8CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
MALMyelin and lymphocyte protein; Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function; Belongs to the MAL family (153 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily (524 aa)
CMTM4CKLF like MARVEL transmembrane domain containing 4 (234 aa)
CMTM7CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family (175 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5; Belongs to the chemokine-like factor family (223 aa)
ACBD3Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins (528 aa)
TMEM35Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth (167 aa)
ZMYM6NBTransmembrane protein 35B; ZMYM6 neighbor (154 aa)
SLC28A3Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine; Solute carriers (691 aa)
PLP2Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium (152 aa)
SLC2A5Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity); Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transport [...] (501 aa)
CMTM1CKLF like MARVEL transmembrane domain containing 1 (286 aa)
SLC22A18Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney; Solute carriers (424 aa)
MYADMMyeloid associated differentiation marker; Belongs to the MAL family (322 aa)
MYADML2Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2 (307 aa)
CMTM3CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family (182 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily (492 aa)
MARVELD1MARVEL domain-containing protein 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (173 aa)
CKLF-CMTM1CKLF-CMTM1 readthrough (168 aa)
MAL2Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (176 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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