26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPL18A	Ribosomal protein L18a (176 aa)
	RPL19	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family (196 aa)
	RPS12	Ribosomal protein S12 (132 aa)
	RPS16	Ribosomal protein S16 (146 aa)
	EEFSEC	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP (596 aa)
	RPL35	60S ribosomal protein L35; Component of the large ribosomal subunit (123 aa)
	RPL8	60S ribosomal protein L8; Component of the large ribosomal subunit (257 aa)
	RPL3L	Ribosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family (407 aa)
	RPS11	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family (158 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be inv [...] (156 aa)
	RPL37	60S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins (97 aa)
	RPS3	40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein [...] (259 aa)
	RPL39L	Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family (51 aa)
	RPS23	40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
	RPL10L	60S ribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis; L ribosomal proteins (214 aa)
	RPS9	Ribosomal protein S9 (194 aa)
	RPL13	Ribosomal protein L13 (211 aa)
	RPL15	Ribosomal protein L15 (204 aa)
	RPL38	Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family (70 aa)
	RPL4	L ribosomal proteins (427 aa)
	RPS15A	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family (130 aa)
	RPLP2	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; L ribosomal proteins (115 aa)
	RPS27L	Ribosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family (84 aa)
	RPS7	40S ribosomal protein S7; Required for rRNA maturation; Belongs to the eukaryotic ribosomal protein eS7 family (194 aa)
	RPL7	60S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (248 aa)
	SECISBP2	Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB (854 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEFSEC	RPL10L	ENSP00000254730	ENSP00000298283	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	60S ribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis; L ribosomal proteins	0.936
EEFSEC	RPL13	ENSP00000254730	ENSP00000307889	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L13	0.933
EEFSEC	RPL15	ENSP00000254730	ENSP00000309334	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L15	0.931
EEFSEC	RPL18A	ENSP00000254730	ENSP00000222247	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L18a	0.910
EEFSEC	RPL19	ENSP00000254730	ENSP00000225430	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family	0.909
EEFSEC	RPL35	ENSP00000254730	ENSP00000259469	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	60S ribosomal protein L35; Component of the large ribosomal subunit	0.939
EEFSEC	RPL37	ENSP00000254730	ENSP00000274242	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	60S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins	0.902
EEFSEC	RPL38	ENSP00000254730	ENSP00000309830	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family	0.907
EEFSEC	RPL39L	ENSP00000254730	ENSP00000296277	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family	0.915
EEFSEC	RPL3L	ENSP00000254730	ENSP00000268661	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family	0.947
EEFSEC	RPL4	ENSP00000254730	ENSP00000311430	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	L ribosomal proteins	0.946
EEFSEC	RPL7	ENSP00000254730	ENSP00000339795	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	60S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs	0.936
EEFSEC	RPL8	ENSP00000254730	ENSP00000262584	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	60S ribosomal protein L8; Component of the large ribosomal subunit	0.950
EEFSEC	RPLP2	ENSP00000254730	ENSP00000322419	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; L ribosomal proteins	0.907
EEFSEC	RPS11	ENSP00000254730	ENSP00000270625	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family	0.966
EEFSEC	RPS12	ENSP00000254730	ENSP00000230050	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein S12	0.943
EEFSEC	RPS15A	ENSP00000254730	ENSP00000318646	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family	0.947
EEFSEC	RPS16	ENSP00000254730	ENSP00000251453	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ribosomal protein S16	0.947
EEFSEC	RPS23	ENSP00000254730	ENSP00000296674	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]	0.942
EEFSEC	RPS27A	ENSP00000254730	ENSP00000272317	Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Ubiquitin-40S ribosomal protein S27a; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be inv [...]	0.919

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