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  • 11.0 [archived version]
STRINGSTRING
FAT1 FAT1 KRAS KRAS FAT3 FAT3 HRAS HRAS NRAS NRAS ATP9B ATP9B SLC31A1 SLC31A1 CD97 CD97 LPAR1 LPAR1 ATP9A ATP9A ZDHHC18 ZDHHC18 SLC31A2 SLC31A2 RRAS2 RRAS2 IL9R IL9R ENSG00000258466 ENSG00000258466 RTDR1 RTDR1 EEF1A1 EEF1A1 STX17 STX17 GSPT1 GSPT1 VTI1A VTI1A EEF1A2 EEF1A2 ETF1 ETF1 GSPT2 GSPT2 VTI1B VTI1B HBS1L HBS1L TRMT12 TRMT12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RTDR1Radial spoke head 14 homolog; Rhabdoid tumor deletion region gene 1; Belongs to the flagellar radial spoke RSP14 family (348 aa)
EEF1A2Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily (463 aa)
CD97CD97 antigen; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity); Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily (835 aa)
IL9RInterleukin-9 receptor; This is a receptor for interleukin-9; Belongs to the type I cytokine receptor family. Type 4 subfamily (521 aa)
KRASGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner; Belongs to the small GTPase superfamily. Ras family (189 aa)
RRAS2Ras-related protein R-Ras2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion (204 aa)
SLC31A2Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake; Solute carriers (143 aa)
STX17Syntaxin-17; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediat [...] (302 aa)
TRMT12tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha- carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family (448 aa)
EEF1A1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily (462 aa)
GSPT2Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (628 aa)
ATP9AProbable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A (1047 aa)
ETF1Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (437 aa)
HBS1LHBS1-like protein; HBS1 like translational GTPase; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family (684 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
ZDHHC18Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK; Zinc fingers DHHC-type (388 aa)
SLC31A1High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake; Solute carriers (190 aa)
LPAR1Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] (364 aa)
VTI1AVesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular [...] (217 aa)
ATP9BProbable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B (1147 aa)
GSPT1Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily (637 aa)
FAT1Protocadherin Fat 1; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact; Cadherin related (4588 aa)
HRASGTPase HRas; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family (189 aa)
FAT3Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related (4439 aa)
ENSG00000258466annotation not available (91 aa)
VTI1BVesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence; Belongs to the VTI1 family (232 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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