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  • 11.0 [archived version]
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SLC6A2 SLC6A2 SLC6A3 SLC6A3 SLC38A10 SLC38A10 SLC6A16 SLC6A16 SLC6A15 SLC6A15 SLC6A4 SLC6A4 SLC18A3 SLC18A3 SLC6A5 SLC6A5 TOP2B TOP2B TOP2A TOP2A SLC6A20 SLC6A20 SLC6A19 SLC6A19 SLC6A18 SLC6A18 SLC38A6 SLC38A6 ENSG00000273554 ENSG00000273554 SLC6A9 SLC6A9 SLC6A12 SLC6A12 SLC32A1 SLC32A1 CCDC167 CCDC167 SLC6A8 SLC6A8 SLC6A17 SLC6A17 SLC6A11 SLC6A11 ENSG00000124208 ENSG00000124208 SLC6A1 SLC6A1 SLC6A6 SLC6A6 SLC6A13 SLC6A13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SLC32A1Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers (525 aa)
SLC6A2Sodium-dependent noradrenaline transporter; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily (628 aa)
SLC6A8Sodium- and chloride-dependent creatine transporter 1; Required for the uptake of creatine in muscles and brain; Solute carriers (635 aa)
SLC6A11Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily (632 aa)
SLC6A4Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily (630 aa)
SLC6A15Sodium-dependent neutral amino acid transporter B(0)AT2; Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1-1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent; Solute carriers (730 aa)
SLC6A3Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals; Solute carriers (620 aa)
SLC6A1Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily (599 aa)
SLC6A19Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily (634 aa)
SLC6A18Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily (628 aa)
SLC6A17Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity); Solute carriers (727 aa)
SLC6A16Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5; Solute carrier family 6 member 16 (736 aa)
SLC6A13Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport; Solute carriers (602 aa)
ENSG00000124208TMEM189-UBE2V1 readthrough; Belongs to the ubiquitin-conjugating enzyme family (370 aa)
SLC6A20Sodium- and chloride-dependent transporter XTRP3; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine; Solute carriers (592 aa)
SLC38A6Probable sodium-coupled neutral amino acid transporter 6; Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate; Solute carriers (521 aa)
SLC6A9Sodium- and chloride-dependent glycine transporter 1; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission; Solute carriers (706 aa)
CCDC167Coiled-coil domain containing 167 (97 aa)
SLC18A3Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers (532 aa)
SLC38A10Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter; Solute carriers (1119 aa)
TOP2BDNA topoisomerase 2-beta; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks; Belongs to the type II topoisomerase family (1621 aa)
SLC6A12Sodium- and chloride-dependent betaine transporter; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation; Solute carriers (614 aa)
TOP2ADNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity); Topoisomerases (1531 aa)
SLC6A5Sodium- and chloride-dependent glycine transporter 2; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily (797 aa)
ENSG00000273554annotation not available (635 aa)
SLC6A6Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake; Solute carriers (620 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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