12 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	CAP2	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family (477 aa)
	CSAD	Cysteine sulfinic acid decarboxylase (520 aa)
	FCRL4	Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response; CD molecules (515 aa)
	GADL1	Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family (521 aa)
	FYCO1	FYVE and coiled-coil domain-containing protein 1; May mediate microtubule plus end-directed vesicle transport; GOLD domain containing (1478 aa)
	ZNF212	Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type (495 aa)
	GAD1	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family (594 aa)
	FAM76B	Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family (339 aa)
	KCNJ10	ATP-sensitive inward rectifier potassium channel 10; May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellu [...] (379 aa)
	ADO	2-aminoethanethiol dioxygenase (270 aa)
	GAD2	Glutamate decarboxylase 2; Catalyzes the production of GABA (585 aa)
	C5orf24	UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family (188 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADO	CSAD	ENSP00000362888	ENSP00000267085	2-aminoethanethiol dioxygenase	Cysteine sulfinic acid decarboxylase	0.951
ADO	FAM76B	ENSP00000362888	ENSP00000351631	2-aminoethanethiol dioxygenase	Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family	0.513
ADO	FCRL4	ENSP00000362888	ENSP00000271532	2-aminoethanethiol dioxygenase	Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response; CD molecules	0.416
ADO	GAD1	ENSP00000362888	ENSP00000350928	2-aminoethanethiol dioxygenase	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	0.900
ADO	GAD2	ENSP00000362888	ENSP00000365437	2-aminoethanethiol dioxygenase	Glutamate decarboxylase 2; Catalyzes the production of GABA	0.900
ADO	GADL1	ENSP00000362888	ENSP00000282538	2-aminoethanethiol dioxygenase	Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family	0.939
CSAD	ADO	ENSP00000267085	ENSP00000362888	Cysteine sulfinic acid decarboxylase	2-aminoethanethiol dioxygenase	0.951
CSAD	GAD1	ENSP00000267085	ENSP00000350928	Cysteine sulfinic acid decarboxylase	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	0.807
CSAD	GAD2	ENSP00000267085	ENSP00000365437	Cysteine sulfinic acid decarboxylase	Glutamate decarboxylase 2; Catalyzes the production of GABA	0.837
CSAD	GADL1	ENSP00000267085	ENSP00000282538	Cysteine sulfinic acid decarboxylase	Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family	0.805
FAM76B	ADO	ENSP00000351631	ENSP00000362888	Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family	2-aminoethanethiol dioxygenase	0.513
FCRL4	ADO	ENSP00000271532	ENSP00000362888	Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response; CD molecules	2-aminoethanethiol dioxygenase	0.416
GAD1	ADO	ENSP00000350928	ENSP00000362888	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	2-aminoethanethiol dioxygenase	0.900
GAD1	CSAD	ENSP00000350928	ENSP00000267085	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	Cysteine sulfinic acid decarboxylase	0.807
GAD1	GAD2	ENSP00000350928	ENSP00000365437	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	Glutamate decarboxylase 2; Catalyzes the production of GABA	0.956
GAD1	GADL1	ENSP00000350928	ENSP00000282538	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family	0.810
GAD2	ADO	ENSP00000365437	ENSP00000362888	Glutamate decarboxylase 2; Catalyzes the production of GABA	2-aminoethanethiol dioxygenase	0.900
GAD2	CSAD	ENSP00000365437	ENSP00000267085	Glutamate decarboxylase 2; Catalyzes the production of GABA	Cysteine sulfinic acid decarboxylase	0.837
GAD2	GAD1	ENSP00000365437	ENSP00000350928	Glutamate decarboxylase 2; Catalyzes the production of GABA	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family	0.956
GAD2	GADL1	ENSP00000365437	ENSP00000282538	Glutamate decarboxylase 2; Catalyzes the production of GABA	Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family	0.838

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