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  • 11.0 [archived version]
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LIPF LIPF LIPM LIPM ABHD8 ABHD8 LIPA LIPA PPME1 PPME1 ABHD11 ABHD11 ABHD10 ABHD10 SERHL2 SERHL2 LIPN LIPN ABHD5 ABHD5 PDE4B PDE4B PDE4D PDE4D SLC29A3 SLC29A3 ABHD14A ABHD14A ABHD4 ABHD4 EPHX3 EPHX3 PDE4A PDE4A BPHL BPHL ADORA2B ADORA2B MEST MEST LIPJ LIPJ PDE4C PDE4C EPHX4 EPHX4 ENSG00000258555 ENSG00000258555 LIPK LIPK ADORA2A ADORA2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EPHX3Epoxide hydrolase 3; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin; Abhydrolase domain containing (360 aa)
ABHD11Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily (315 aa)
MESTMesoderm-specific transcript homolog protein; Mesoderm specific transcript; Belongs to the AB hydrolase superfamily (335 aa)
ABHD8Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily (439 aa)
ABHD10Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate; Belongs to the AB hydrolase superfamily (306 aa)
ABHD14AProtein ABHD14A; Possible role in granule neuron development; Abhydrolase domain containing (271 aa)
ADORA2BAdenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (332 aa)
SERHL2Serine hydrolase-like protein 2; Probable serine hydrolase. May be related to cell muscle hypertrophy (314 aa)
PDE4BcAMP-specific 3’,5’-cyclic phosphodiesterase 4B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents; Phosphodiesterases (736 aa)
ADORA2AAdenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family (412 aa)
LIPALysosomal acid lipase/cholesteryl ester hydrolase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation; Belongs to the AB hydrolase superfamily. Lipase family (399 aa)
PDE4DcAMP-specific 3’,5’-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily (809 aa)
PDE4CcAMP-specific 3’,5’-cyclic phosphodiesterase 4C; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily (712 aa)
EPHX4Epoxide hydrolase 4; Abhydrolase domain containing (362 aa)
LIPJLipase family member J; Belongs to the AB hydrolase superfamily. Lipase family (366 aa)
SLC29A3Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine; Solute carriers (475 aa)
BPHLValacyclovir hydrolase; Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol; Belongs to the AB hydrolase superfamily. Lipase family (291 aa)
PDE4AcAMP-specific 3’,5’-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily (886 aa)
LIPFLipase F, gastric type; Lipases (408 aa)
PPME1Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme; Protein phosphatase 2 modulatory subunits (400 aa)
LIPKLipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases (399 aa)
LIPMLipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Belongs to the AB hydrolase superfamily. Lipase family (423 aa)
LIPNLipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases (398 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity); Abhydrolase domain containing (349 aa)
ABHD4Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethan [...] (342 aa)
ENSG00000258555Adenosine receptor A2a; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family (412 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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