7 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AURKA	Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDE [...] (403 aa)
	USP11	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...] (963 aa)
	TCEAL1	Transcription elongation factor A like family (159 aa)
	TCEAL4	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family (358 aa)
	TCEAL2	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family (227 aa)
	LRRFIP1	Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (808 aa)
	PCDHA12	Protocadherin alpha-12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (941 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCEAL1	TCEAL2	ENSP00000361708	ENSP00000361866	Transcription elongation factor A like family	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.651
TCEAL1	TCEAL4	ENSP00000361708	ENSP00000361712	Transcription elongation factor A like family	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.913
TCEAL1	USP11	ENSP00000361708	ENSP00000218348	Transcription elongation factor A like family	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...]	0.839
TCEAL2	TCEAL1	ENSP00000361866	ENSP00000361708	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family	Transcription elongation factor A like family	0.651
TCEAL2	TCEAL4	ENSP00000361866	ENSP00000361712	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.599
TCEAL2	USP11	ENSP00000361866	ENSP00000218348	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...]	0.523
TCEAL4	TCEAL1	ENSP00000361712	ENSP00000361708	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family	Transcription elongation factor A like family	0.913
TCEAL4	TCEAL2	ENSP00000361712	ENSP00000361866	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.599
TCEAL4	USP11	ENSP00000361712	ENSP00000218348	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...]	0.521
USP11	TCEAL1	ENSP00000218348	ENSP00000361708	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...]	Transcription elongation factor A like family	0.839
USP11	TCEAL2	ENSP00000218348	ENSP00000361866	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...]	Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.523
USP11	TCEAL4	ENSP00000218348	ENSP00000361712	Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...]	Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.521

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About