node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHERP | FRA10AC1 | ENSP00000439856 | ENSP00000360488 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | 0.511 |
CHERP | RBM39 | ENSP00000439856 | ENSP00000253363 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process; RNA binding motif containing | 0.806 |
CHERP | SF3B2 | ENSP00000439856 | ENSP00000318861 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.912 |
CHERP | SNIP1 | ENSP00000439856 | ENSP00000296215 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | Smad nuclear-interacting protein 1; Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3’end of the CCND1 gene and its mRNA | 0.541 |
CHERP | SNW1 | ENSP00000439856 | ENSP00000261531 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.924 |
CHERP | SRRM2 | ENSP00000439856 | ENSP00000301740 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family | 0.918 |
CHERP | TMCO2 | ENSP00000439856 | ENSP00000361852 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | Transmembrane and coiled-coil domains 2 | 0.511 |
DGCR14 | FRA10AC1 | ENSP00000252137 | ENSP00000360488 | Protein DGCR14; May be involved in pre-mRNA splicing | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | 0.828 |
DGCR14 | SNW1 | ENSP00000252137 | ENSP00000261531 | Protein DGCR14; May be involved in pre-mRNA splicing | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.466 |
DGCR14 | TMCO2 | ENSP00000252137 | ENSP00000361852 | Protein DGCR14; May be involved in pre-mRNA splicing | Transmembrane and coiled-coil domains 2 | 0.594 |
FRA10AC1 | CHERP | ENSP00000360488 | ENSP00000439856 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing | 0.511 |
FRA10AC1 | DGCR14 | ENSP00000360488 | ENSP00000252137 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Protein DGCR14; May be involved in pre-mRNA splicing | 0.828 |
FRA10AC1 | IK | ENSP00000360488 | ENSP00000396301 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Protein Red; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1 | 0.518 |
FRA10AC1 | NKAP | ENSP00000360488 | ENSP00000360464 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family | 0.519 |
FRA10AC1 | SF3B2 | ENSP00000360488 | ENSP00000318861 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.518 |
FRA10AC1 | TMCO2 | ENSP00000360488 | ENSP00000361852 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | Transmembrane and coiled-coil domains 2 | 0.514 |
IK | FRA10AC1 | ENSP00000396301 | ENSP00000360488 | Protein Red; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex | 0.518 |
IK | SF3B2 | ENSP00000396301 | ENSP00000318861 | Protein Red; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1 | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.610 |
IK | SNIP1 | ENSP00000396301 | ENSP00000296215 | Protein Red; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1 | Smad nuclear-interacting protein 1; Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3’end of the CCND1 gene and its mRNA | 0.546 |
IK | TMCO2 | ENSP00000396301 | ENSP00000361852 | Protein Red; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1 | Transmembrane and coiled-coil domains 2 | 0.511 |