• Version:
  • 11.0 [archived version]
STRINGSTRING
PLN PLN ZNF395 ZNF395 LDLRAD1 LDLRAD1 SLC1A1 SLC1A1 GPR128 GPR128 OLFM4 OLFM4 PTTG1IP PTTG1IP TMEM147 TMEM147 SLC25A22 SLC25A22 LAPTM5 LAPTM5 TMEM218 TMEM218 GIMAP5 GIMAP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OLFM4Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin (510 aa)
TMEM147Transmembrane protein 147 (224 aa)
SLC1A1Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorptio [...] (524 aa)
GPR128Adhesion G-protein coupled receptor G7; Orphan receptor (797 aa)
LAPTM5Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family (262 aa)
SLC25A22Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+); Belongs to the mitochondrial carrier (TC 2.A.29) family (323 aa)
PTTG1IPPituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation (180 aa)
ZNF395Zinc finger protein 395; Plays a role in papillomavirus genes transcription; Zinc fingers C2H2-type (513 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation; Belongs to the phospholamban family (52 aa)
LDLRAD1Low density lipoprotein receptor class A domain containing 1 (205 aa)
TMEM218Transmembrane protein 218; May be involved in ciliary biogenesis or function (115 aa)
GIMAP5GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP (511 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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