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PRSS21 | Testisin; Could regulate proteolytic events associated with testicular germ cell maturation; Serine proteases (314 aa) | |||
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] (335 aa) | |||
APOB | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor; Apolipoproteins (4563 aa) | |||
CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family (527 aa) | |||
KLK12 | Kallikrein-12; Kallikrein related peptidase 12; Belongs to the peptidase S1 family. Kallikrein subfamily (254 aa) | |||
LAMC1 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (1609 aa) | |||
RSAD1 | Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be involved in porphyrin cofactor biosynthesis; Belongs to the anaerobic coproporphyrinogen-III oxidase family (442 aa) | |||
CLPS | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase (112 aa) | |||
LMF1 | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL (567 aa) | |||
ETNK1 | Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis (452 aa) | |||
SUMF1 | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family (374 aa) | |||
TMPRSS15 | Enteropeptidase; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases; Scavenger receptor cysteine rich domain containing (1019 aa) | |||
CELA3A | Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | |||
PCYT1A | Choline-phosphate cytidylyltransferase A; Controls phosphatidylcholine synthesis; Belongs to the cytidylyltransferase family (367 aa) | |||
CELA1 | Chymotrypsin-like elastase family member 1; Acts upon elastin (258 aa) | |||
ANPEP | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases (967 aa) | |||
KLK1 | Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily (262 aa) | |||
CTRB2 | Chymotrypsinogen B2; Belongs to the peptidase S1 family (263 aa) | |||
F2 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family (622 aa) | |||
ZGPAT | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5’- GGAG[GA]A[GA]A-3’ consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis; G-patch domain containing (531 aa) | |||
ZNF444 | Zinc finger protein 444; Transcriptional regulator. Binds to the 5’-flanking critical region of the SCARF1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family (327 aa) | |||
GPAA1 | Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate (621 aa) | |||
PNLIP | Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family (465 aa) | |||
PCYT1B | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis (369 aa) | |||
TF | Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (698 aa) | |||
ZNF787 | Zinc finger protein 787; May be involved in transcriptional regulation; Zinc fingers C2H2-type (382 aa) |