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| PKP2 | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing (881 aa) | |||
| TGM1 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family (817 aa) | |||
| PI3 | Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing (117 aa) | |||
| CAPNS1 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing (268 aa) | |||
| DSG3 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins (999 aa) | |||
| DSG1 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins (1049 aa) | |||
| DSC1 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues; Desmosomal cadherins (894 aa) | |||
| DSG2 | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins (1118 aa) | |||
| PKP1 | Plakophilin-1; Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis; Armadillo repeat containing (747 aa) | |||
| CSTA | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family (98 aa) | |||
| ST14 | Suppressor of tumorigenicity 14 protein; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing; Serine proteases (855 aa) | |||
| DSC2 | Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins (901 aa) | |||
| EVPL | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins (2033 aa) | |||
| SPRR1B | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family (89 aa) | |||
| RPTN | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing (784 aa) | |||
| PRSS8 | Prostasin; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G); Serine proteases (343 aa) | |||
| SPRR3 | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins (169 aa) | |||
| PKP3 | Plakophilin-3; May play a role in junctional plaques; Armadillo repeat containing (797 aa) | |||
| PPL | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family (1756 aa) | |||
| CELA2A | Chymotrypsin-like elastase family member 2A; Acts upon elastin (269 aa) | |||
| DSG4 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity); Desmosomal cadherins (1059 aa) | |||
| DSC3 | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins (896 aa) | |||
| LOR | Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family (312 aa) | |||
| SPRR2G | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity); Small proline rich proteins (73 aa) | |||
| SPRR2E | Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins (72 aa) | |||
| FLG | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing (4061 aa) | |||
