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  • 11.0 [archived version]
STRINGSTRING
SMCP SMCP KRTAP10-10 KRTAP10-10 RGS17 RGS17 LCE1E LCE1E LCE1C LCE1C LCE4A LCE4A LCE5A LCE5A TGFB1 TGFB1 LCE1F LCE1F LCE1D LCE1D LCE2C LCE2C LCE3A LCE3A LCE3B LCE3B LCE2D LCE2D LCE2B LCE2B LCE1B LCE1B CRCT1 CRCT1 LCE3D LCE3D LCE1A LCE1A KRTAP5-2 KRTAP5-2 PTPMT1 PTPMT1 RGS20 RGS20 KRTAP5-4 KRTAP5-4 CYP21A2 CYP21A2 KRTAP5-11 KRTAP5-11 KRTAP4-4 KRTAP4-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...] (390 aa)
RGS20Regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) (388 aa)
LCE1DLate cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum (114 aa)
PTPMT1Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for p [...] (201 aa)
LCE5ALate cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (118 aa)
LCE1FLate cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE1ALate cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE3ALate cornified envelope protein 3A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (89 aa)
LCE3BLate cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (95 aa)
LCE1BLate cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum (118 aa)
RGS17Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) (210 aa)
SMCPSperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) (116 aa)
LCE1ELate cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE4ALate cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (99 aa)
LCE2BLate cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE2CLate cornified envelope protein 2C; Precursors of the cornified envelope of the stratum (110 aa)
LCE2DLate cornified envelope protein 2D; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE3DLate cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (92 aa)
CRCT1Cysteine rich C-terminal 1 (99 aa)
KRTAP10-10Keratin-associated protein 10-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (251 aa)
KRTAP4-4Keratin-associated protein 4-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (166 aa)
KRTAP5-11Keratin-associated protein 5-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family (156 aa)
KRTAP5-4Keratin associated protein 5-4 (228 aa)
KRTAP5-2Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family (177 aa)
CYP21A2Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids; Cytochrome P450 family 21 (495 aa)
LCE1CLate cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum (118 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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