• Version:
  • 11.0 [archived version]
STRINGSTRING
KRT40 KRT40 KRT20 KRT20 KRT12 KRT12 KRT13 KRT13 KRT28 KRT28 KRT31 KRT31 KRT9 KRT9 KRT14 KRT14 KRT38 KRT38 KRT27 KRT27 KRT33B KRT33B KRT33A KRT33A KRT32 KRT32 MAPK14 MAPK14 KRT24 KRT24 KRT37 KRT37 KRT25 KRT25 KRT19 KRT19 KRT36 KRT36 KRT10 KRT10 MAPK11 MAPK11 KRT26 KRT26 KRT17 KRT17 KRT39 KRT39 KRT23 KRT23 KRT16 KRT16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRT33AKeratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family (404 aa)
KRT14Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
KRT20Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I (424 aa)
KRT23Keratin, type I cytoskeletal 23; Keratins, type I (422 aa)
KRT37Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family (449 aa)
KRT32Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
KRT13Keratin, type I cytoskeletal 13; Keratins, type I (458 aa)
KRT38Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
KRT9Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family (623 aa)
KRT12Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Keratins, type I (494 aa)
KRT31Keratin, type I cuticular Ha1; Keratins, type I (416 aa)
KRT33BKeratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family (404 aa)
KRT24Keratin, type I cytoskeletal 24; Keratins, type I (525 aa)
KRT10Keratin, type I cytoskeletal 10; Keratins, type I (584 aa)
KRT16Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance (473 aa)
KRT27Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (459 aa)
KRT28Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs) (464 aa)
KRT17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] (432 aa)
KRT25Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (450 aa)
KRT36Keratin, type I cuticular Ha6; Keratins, type I (467 aa)
MAPK11Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...] (364 aa)
KRT26Keratin, type I cytoskeletal 26; Keratins, type I; Belongs to the intermediate filament family (468 aa)
KRT39Keratin, type I cytoskeletal 39; May play a role in late hair differentiation; Belongs to the intermediate filament family (491 aa)
KRT19Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I (400 aa)
KRT40Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family (431 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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