node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APPL1 | APPL2 | ENSP00000288266 | ENSP00000446917 | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway; BAR-PH domain containing | DCC-interacting protein 13-beta; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction; BAR-PH domain containing | 0.531 |
APPL2 | APPL1 | ENSP00000446917 | ENSP00000288266 | DCC-interacting protein 13-beta; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction; BAR-PH domain containing | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway; BAR-PH domain containing | 0.531 |
ASF1A | ASF1B | ENSP00000229595 | ENSP00000263382 | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; Belongs to the ASF1 family | Histone chaperone ASF1B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis; Belongs to the ASF1 family | 0.554 |
ASF1B | ASF1A | ENSP00000263382 | ENSP00000229595 | Histone chaperone ASF1B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis; Belongs to the ASF1 family | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; Belongs to the ASF1 family | 0.554 |
ME1 | ME2 | ENSP00000358719 | ENSP00000321070 | Malic enzyme 1 | NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family | 0.809 |
ME1 | ME3 | ENSP00000358719 | ENSP00000440246 | Malic enzyme 1 | NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family | 0.809 |
ME2 | ME1 | ENSP00000321070 | ENSP00000358719 | NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family | Malic enzyme 1 | 0.809 |
ME2 | ME3 | ENSP00000321070 | ENSP00000440246 | NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family | NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family | 0.809 |
ME3 | ME1 | ENSP00000440246 | ENSP00000358719 | NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family | Malic enzyme 1 | 0.809 |
ME3 | ME2 | ENSP00000440246 | ENSP00000321070 | NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family | NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family | 0.809 |
MPC1 | MPC2 | ENSP00000354223 | ENSP00000356820 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers | 0.998 |
MPC1 | SLC25A20 | ENSP00000354223 | ENSP00000326305 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway; Solute carriers | 0.407 |
MPC2 | MPC1 | ENSP00000356820 | ENSP00000354223 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family | 0.998 |
MPC2 | SLC25A20 | ENSP00000356820 | ENSP00000326305 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway; Solute carriers | 0.553 |
SLC25A20 | MPC1 | ENSP00000326305 | ENSP00000354223 | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway; Solute carriers | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family | 0.407 |
SLC25A20 | MPC2 | ENSP00000326305 | ENSP00000356820 | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway; Solute carriers | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers | 0.553 |