Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Armadillo-like helical domain containing

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...]

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...]

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...]

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness; WD repeat domain containing

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Protein MAK16 homolog; RNA binding motif containing

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)

Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit

Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family