• Version:
  • 11.0 [archived version]
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MARVELD1 MARVELD1 CMTM4 CMTM4 PLP2 PLP2 FAM114A1 FAM114A1 PPAT PPAT CMTM1 CMTM1 CMTM5 CMTM5 GDAP1 GDAP1 CMTM3 CMTM3 CKLF CKLF MYADM MYADM CMTM8 CMTM8 CMTM6 CMTM6 PLLP PLLP RSU1 RSU1 CMTM2 CMTM2 CMTM7 CMTM7 SPG21 SPG21 RAB2A RAB2A RAB2B RAB2B MAL MAL THUMPD3 THUMPD3 SEC24D SEC24D MYADML2 MYADML2 TLN1 TLN1 TENC1 TENC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPG21Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation (308 aa)
CMTM6CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family (183 aa)
PLLPPlasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family (182 aa)
GDAP1Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission (358 aa)
RAB2ARas-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases (212 aa)
CKLFChemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa)
PPATAmidophosphoribosyltransferase; Phosphoribosyl pyrophosphate amidotransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family (517 aa)
CMTM2CKLF like MARVEL transmembrane domain containing 2; Belongs to the chemokine-like factor family (248 aa)
SEC24DProtein transport protein Sec24D; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor [...] (1032 aa)
CMTM8CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
MALMyelin and lymphocyte protein; Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function; Belongs to the MAL family (153 aa)
TLN1Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity); FERM domain containing (2541 aa)
TENC1Tensin-2; Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling (1419 aa)
CMTM4CKLF like MARVEL transmembrane domain containing 4 (234 aa)
CMTM7CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family (175 aa)
THUMPD3THUMP domain-containing protein 3; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily (507 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5; Belongs to the chemokine-like factor family (223 aa)
FAM114A1Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family (563 aa)
PLP2Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium (152 aa)
RSU1Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (277 aa)
CMTM1CKLF like MARVEL transmembrane domain containing 1 (286 aa)
MYADMMyeloid associated differentiation marker; Belongs to the MAL family (322 aa)
RAB2BRas-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases (216 aa)
MYADML2Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2 (307 aa)
CMTM3CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family (182 aa)
MARVELD1MARVEL domain-containing protein 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (173 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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