15 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

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Your Input:
	NCLN	Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family (563 aa)
	C12orf49	UPF0454 protein C12orf49; Chromosome 12 open reading frame 49; Belongs to the UPF0454 family (205 aa)
	C12orf10	UPF0160 protein MYG1, mitochondrial; Chromosome 12 open reading frame 10 (376 aa)
	NOMO1	Nodal modulator 1; May antagonize Nodal signaling (1222 aa)
	SERINC1	Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family (453 aa)
	METTL9	Methyltransferase-like protein 9; Methyltransferase like 9 (318 aa)
	GCNT2	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells; Belongs to the glycosyltransferase 14 family (402 aa)
	AGPAT3	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...] (376 aa)
	TMEM120B	Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family (339 aa)
	ST3GAL1	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; Responsible for the synthesis of the sequence NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values; Belongs to the glycosyltransferase 29 family (340 aa)
	ARL15	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family (204 aa)
	ARMC6	Armadillo repeat containing 6 (501 aa)
	DPEP2	Dipeptidase 2; Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (486 aa)
	ZFP36	mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3’-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compone [...] (332 aa)
	TMEM120A	Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family (343 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGPAT3	ARL15	ENSP00000381140	ENSP00000433427	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	0.546
AGPAT3	METTL9	ENSP00000381140	ENSP00000350874	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	Methyltransferase-like protein 9; Methyltransferase like 9	0.537
AGPAT3	NCLN	ENSP00000381140	ENSP00000246117	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family	0.536
AGPAT3	NOMO1	ENSP00000381140	ENSP00000287667	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	Nodal modulator 1; May antagonize Nodal signaling	0.527
AGPAT3	SERINC1	ENSP00000381140	ENSP00000342962	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family	0.527
AGPAT3	TMEM120A	ENSP00000381140	ENSP00000473983	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family	0.536
AGPAT3	TMEM120B	ENSP00000381140	ENSP00000404991	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family	0.536
ARL15	AGPAT3	ENSP00000433427	ENSP00000381140	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	0.546
ARL15	METTL9	ENSP00000433427	ENSP00000350874	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Methyltransferase-like protein 9; Methyltransferase like 9	0.527
ARL15	NCLN	ENSP00000433427	ENSP00000246117	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family	0.527
ARL15	NOMO1	ENSP00000433427	ENSP00000287667	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Nodal modulator 1; May antagonize Nodal signaling	0.527
ARL15	SERINC1	ENSP00000433427	ENSP00000342962	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family	0.527
ARL15	TMEM120A	ENSP00000433427	ENSP00000473983	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family	0.527
ARL15	TMEM120B	ENSP00000433427	ENSP00000404991	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family	0.527
GCNT2	ST3GAL1	ENSP00000368917	ENSP00000428540	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells; Belongs to the glycosyltransferase 14 family	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; Responsible for the synthesis of the sequence NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values; Belongs to the glycosyltransferase 29 family	0.454
METTL9	AGPAT3	ENSP00000350874	ENSP00000381140	Methyltransferase-like protein 9; Methyltransferase like 9	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16-0-C20-4 at the sn-1 position using C18-1, C20-4 or C18-2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18-1 or C20-4-CoA. Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lys [...]	0.537
METTL9	ARL15	ENSP00000350874	ENSP00000433427	Methyltransferase-like protein 9; Methyltransferase like 9	ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family	0.527
METTL9	NCLN	ENSP00000350874	ENSP00000246117	Methyltransferase-like protein 9; Methyltransferase like 9	Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family	0.527
METTL9	NOMO1	ENSP00000350874	ENSP00000287667	Methyltransferase-like protein 9; Methyltransferase like 9	Nodal modulator 1; May antagonize Nodal signaling	0.527
METTL9	SERINC1	ENSP00000350874	ENSP00000342962	Methyltransferase-like protein 9; Methyltransferase like 9	Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family	0.527

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