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  • 11.0 [archived version]
STRINGSTRING
LCE3D LCE3D EVPL EVPL LCE3C LCE3C LCE1F LCE1F SPRR3 SPRR3 SPRR2G SPRR2G LCE1A LCE1A LCE5A LCE5A LELP1 LELP1 CSTA CSTA IVL IVL PI3 PI3 SPRR1A SPRR1A LCE3A LCE3A RPTN RPTN PPL PPL LCE1D LCE1D SPRR2B SPRR2B LCE1B LCE1B SPRR2D SPRR2D LCE1E LCE1E SPRR2E SPRR2E LCE4A LCE4A SPRR1B SPRR1B LOR LOR LCE2D LCE2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PI3Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing (117 aa)
CSTACystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family (98 aa)
EVPLEnvoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins (2033 aa)
SPRR1BCornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family (89 aa)
LCE1DLate cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum (114 aa)
RPTNRepetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing (784 aa)
SPRR3Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins (169 aa)
LCE5ALate cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (118 aa)
LCE1FLate cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE3CLate cornified envelope protein 3C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (94 aa)
LCE1ALate cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE3ALate cornified envelope protein 3A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (89 aa)
PPLPeriplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family (1756 aa)
LCE1BLate cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum (118 aa)
LORLoricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family (312 aa)
LELP1Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family (98 aa)
SPRR2GSmall proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity); Small proline rich proteins (73 aa)
SPRR2ESmall proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins (72 aa)
SPRR2BSmall proline-rich protein 2B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins (72 aa)
SPRR2DSmall proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins (72 aa)
SPRR1ACornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins (89 aa)
IVLInvolucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family (585 aa)
LCE1ELate cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum (118 aa)
LCE4ALate cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (99 aa)
LCE2DLate cornified envelope protein 2D; Precursors of the cornified envelope of the stratum corneum (110 aa)
LCE3DLate cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (92 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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