26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

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Your Input:
	KRT33A	Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family (404 aa)
	KRT14	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
	KRT20	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I (424 aa)
	KRT23	Keratin, type I cytoskeletal 23; Keratins, type I (422 aa)
	KRT37	Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family (449 aa)
	KRT32	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
	KRT13	Keratin, type I cytoskeletal 13; Keratins, type I (458 aa)
	KRT38	Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
	KRT9	Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly; Belongs to the intermediate filament family (623 aa)
	KRT12	Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Keratins, type I (494 aa)
	KRT31	Keratin, type I cuticular Ha1; Keratins, type I (416 aa)
	KRT33B	Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family (404 aa)
	KRT5	Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
	KRT1	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
	KRT75	Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (551 aa)
	KRT6C	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family (564 aa)
	KRT6B	Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family (564 aa)
	KRT15	Keratin, type I cytoskeletal 15; Keratins, type I (456 aa)
	KRT85	Keratin, type II cuticular Hb5; Keratins, type II (507 aa)
	KRT71	Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (523 aa)
	KRT74	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II (529 aa)
	SLC19A1	Folate transporter 1; Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump; Minor histocompatibility antigens (591 aa)
	KRT26	Keratin, type I cytoskeletal 26; Keratins, type I; Belongs to the intermediate filament family (468 aa)
	KRT6A	Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair; Belongs to the intermediate filament family (564 aa)
	KRT81	Keratin, type II cuticular Hb1; Keratins, type II (505 aa)
	KRT3	Keratin, type II cytoskeletal 3; Keratins, type II (628 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT1	KRT12	ENSP00000252244	ENSP00000251643	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Keratins, type I	0.944
KRT1	KRT13	ENSP00000252244	ENSP00000246635	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 13; Keratins, type I	0.946
KRT1	KRT14	ENSP00000252244	ENSP00000167586	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.935
KRT1	KRT15	ENSP00000252244	ENSP00000254043	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 15; Keratins, type I	0.947
KRT1	KRT20	ENSP00000252244	ENSP00000167588	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I	0.921
KRT1	KRT23	ENSP00000252244	ENSP00000209718	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 23; Keratins, type I	0.911
KRT1	KRT26	ENSP00000252244	ENSP00000334798	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cytoskeletal 26; Keratins, type I; Belongs to the intermediate filament family	0.910
KRT1	KRT3	ENSP00000252244	ENSP00000413479	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 3; Keratins, type II	0.907
KRT1	KRT31	ENSP00000252244	ENSP00000251645	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha1; Keratins, type I	0.915
KRT1	KRT32	ENSP00000252244	ENSP00000225899	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family	0.921
KRT1	KRT33A	ENSP00000252244	ENSP00000007735	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family	0.908
KRT1	KRT33B	ENSP00000252244	ENSP00000251646	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family	0.915
KRT1	KRT37	ENSP00000252244	ENSP00000225550	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family	0.921
KRT1	KRT38	ENSP00000252244	ENSP00000246646	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family	0.923
KRT1	KRT5	ENSP00000252244	ENSP00000252242	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 5; Keratins, type II	0.997
KRT1	KRT6A	ENSP00000252244	ENSP00000369317	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair; Belongs to the intermediate filament family	0.911
KRT1	KRT6B	ENSP00000252244	ENSP00000252252	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family	0.911
KRT1	KRT6C	ENSP00000252244	ENSP00000252250	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family	0.913
KRT1	KRT71	ENSP00000252244	ENSP00000267119	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle	0.901
KRT1	KRT74	ENSP00000252244	ENSP00000307240	Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type II	0.903

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