• Version:
  • 11.0 [archived version]
STRINGSTRING
ZDHHC7 ZDHHC7 ECSIT ECSIT TMEM186 TMEM186 HEATR3 HEATR3 TM4SF20 TM4SF20 SLC24A5 SLC24A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECSITEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity); Belongs to the ECSIT family (431 aa)
HEATR3HEAT repeat-containing protein 3; Armadillo-like helical domain containing (680 aa)
TM4SF20Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] (229 aa)
TMEM186Transmembrane protein 186 (213 aa)
SLC24A5Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily (500 aa)
ZDHHC7Palmitoyltransferase; Zinc finger DHHC-type containing 7; Belongs to the DHHC palmitoyltransferase family (345 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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