26 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPL19	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family (196 aa)
	RPS12	Ribosomal protein S12 (132 aa)
	RPS16	Ribosomal protein S16 (146 aa)
	RPS3	40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein [...] (259 aa)
	RPS23	40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
	RPL13	Ribosomal protein L13 (211 aa)
	RPL15	Ribosomal protein L15 (204 aa)
	RPS27L	Ribosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family (84 aa)
	RPS2	Ribosomal protein S2 (293 aa)
	RPS21	Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family (83 aa)
	RPL27A	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family (148 aa)
	RPL21	60S ribosomal protein L21; Component of the large ribosomal subunit (160 aa)
	RPL22	Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family (128 aa)
	RPL12	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA (165 aa)
	RPL7A	Ribosomal protein L7a (266 aa)
	RPS4X	Ribosomal protein S4, X-linked; Belongs to the eukaryotic ribosomal protein eS4 family (263 aa)
	RPL10A	60S ribosomal protein L10a; Component of the large ribosomal subunit (217 aa)
	RPS6	40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; S ribosomal proteins (249 aa)
	RPL24	Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family (157 aa)
	RPL23A	60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family (156 aa)
	RPS24	40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family (289 aa)
	RPL37A	Ribosomal protein L37a (92 aa)
	GNB2L1	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily (317 aa)
	RPS20	Ribosomal protein S20 (142 aa)
	RPS25	Ribosomal protein S25 (125 aa)
	RPS28	Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family (69 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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TSV: tab separated values - can be opened in Excel

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNB2L1	RPL10A	ENSP00000426909	ENSP00000363018	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	60S ribosomal protein L10a; Component of the large ribosomal subunit	0.999
GNB2L1	RPL12	ENSP00000426909	ENSP00000354739	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	60S ribosomal protein L12; Binds directly to 26S ribosomal RNA	0.999
GNB2L1	RPL13	ENSP00000426909	ENSP00000307889	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L13	0.999
GNB2L1	RPL15	ENSP00000426909	ENSP00000309334	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L15	0.999
GNB2L1	RPL19	ENSP00000426909	ENSP00000225430	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family	0.999
GNB2L1	RPL21	ENSP00000426909	ENSP00000346027	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	60S ribosomal protein L21; Component of the large ribosomal subunit	0.999
GNB2L1	RPL22	ENSP00000426909	ENSP00000346088	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family	0.998
GNB2L1	RPL23A	ENSP00000426909	ENSP00000389103	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family	0.999
GNB2L1	RPL24	ENSP00000426909	ENSP00000377640	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family	0.998
GNB2L1	RPL27A	ENSP00000426909	ENSP00000346015	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family	0.999
GNB2L1	RPL37A	ENSP00000426909	ENSP00000418082	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L37a	0.999
GNB2L1	RPL7A	ENSP00000426909	ENSP00000361076	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein L7a	0.999
GNB2L1	RPS12	ENSP00000426909	ENSP00000230050	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein S12	0.999
GNB2L1	RPS16	ENSP00000426909	ENSP00000251453	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein S16	0.999
GNB2L1	RPS2	ENSP00000426909	ENSP00000341885	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein S2	0.999
GNB2L1	RPS20	ENSP00000426909	ENSP00000429374	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein S20	0.999
GNB2L1	RPS21	ENSP00000426909	ENSP00000345957	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family	0.999
GNB2L1	RPS23	ENSP00000426909	ENSP00000296674	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]	0.999
GNB2L1	RPS24	ENSP00000426909	ENSP00000414321	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family	0.999
GNB2L1	RPS25	ENSP00000426909	ENSP00000435096	Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily	Ribosomal protein S25	0.999

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