• Version:
  • 11.0 [archived version]
STRINGSTRING
EDEM3 EDEM3 DDRGK1 DDRGK1 SRPR SRPR MRPL24 MRPL24 RPL27 RPL27 RPL34 RPL34 RPL37 RPL37 MRPL27 MRPL27 RPL8 RPL8 RPL39 RPL39 RPL12 RPL12 RPL23 RPL23 RPL31 RPL31 MRPL11 MRPL11 SRPRB SRPRB RPL23A RPL23A RPL11 RPL11 MRPL9 MRPL9 RPL24 RPL24 RPL15 RPL15 SRP54 SRP54 RPL26L1 RPL26L1 MRPL2 MRPL2 RPL37A RPL37A SRP9 SRP9 RPL26 RPL26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRPL27Mitochondrial ribosomal protein L27 (148 aa)
RPL860S ribosomal protein L8; Component of the large ribosomal subunit (257 aa)
RPL3760S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins (97 aa)
SRP9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (86 aa)
MRPL11Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family (192 aa)
RPL15Ribosomal protein L15 (204 aa)
EDEM3ER degradation-enhancing alpha-mannosidase-like protein 3; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity) (932 aa)
SRPRSignal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (638 aa)
DDRGK1DDRGK domain-containing protein 1; Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. May also play a role in the cellular response to endoplasmic reticulum stress (By similarity) (314 aa)
MRPL24Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family (216 aa)
RPL1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA (165 aa)
RPL39Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family (51 aa)
MRPL9Mitochondrial ribosomal protein L9 (267 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] (178 aa)
MRPL2Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family (305 aa)
RPL24Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family (157 aa)
RPL3460S ribosomal protein L34; Component of the large ribosomal subunit (117 aa)
RPL31Ribosomal protein L31 (128 aa)
RPL23A60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family (156 aa)
RPL37ARibosomal protein L37a (92 aa)
SRPRBSignal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) (271 aa)
RPL23Ribosomal protein L23 (140 aa)
RPL26L1Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family (145 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (504 aa)
RPL26Ribosomal protein L26 (145 aa)
RPL2760S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (136 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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