16 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	OSM	Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity) (252 aa)
	ELF1	ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer; Belongs to the ETS family (619 aa)
	ELOF1	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions (83 aa)
	KRAS	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner; Belongs to the small GTPase superfamily. Ras family (189 aa)
	RERG	Ras-related and estrogen-regulated growth inhibitor; Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential; RAS type GTPase family (199 aa)
	WBP11	WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity; Protein phosphatase 1 regulatory subunits (641 aa)
	ACAT1	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism (427 aa)
	DEF8	Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption (512 aa)
	ACAA2	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
	HADHB	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta (474 aa)
	C5orf22	UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family (442 aa)
	ACAA1	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 (424 aa)
	ACAT2	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 (397 aa)
	NRAS	GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
	SURF2	Surfeit 2; Belongs to the SURF2 family (256 aa)
	HRAS	GTPase HRas; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family (189 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAA2	ENSP00000333664	ENSP00000285093	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.843
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.932
ACAA1	ACAT2	ENSP00000333664	ENSP00000356015	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.919
ACAA1	HADHB	ENSP00000333664	ENSP00000325136	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.842
ACAA2	ACAA1	ENSP00000285093	ENSP00000333664	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.843
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.964
ACAA2	ACAT2	ENSP00000285093	ENSP00000356015	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.915
ACAA2	HADHB	ENSP00000285093	ENSP00000325136	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.925
ACAT1	ACAA1	ENSP00000265838	ENSP00000333664	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.932
ACAT1	ACAA2	ENSP00000265838	ENSP00000285093	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.964
ACAT1	ACAT2	ENSP00000265838	ENSP00000356015	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.947
ACAT1	C5orf22	ENSP00000265838	ENSP00000326879	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family	0.711
ACAT1	HADHB	ENSP00000265838	ENSP00000325136	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.940
ACAT2	ACAA1	ENSP00000356015	ENSP00000333664	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.919
ACAT2	ACAA2	ENSP00000356015	ENSP00000285093	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.915
ACAT2	ACAT1	ENSP00000356015	ENSP00000265838	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.947
ACAT2	C5orf22	ENSP00000356015	ENSP00000326879	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family	0.461
ACAT2	HADHB	ENSP00000356015	ENSP00000325136	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.926
C5orf22	ACAT1	ENSP00000326879	ENSP00000265838	UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.711
C5orf22	ACAT2	ENSP00000326879	ENSP00000356015	UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.461

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