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  • 11.0 [archived version]
STRINGSTRING
ACTR1B ACTR1B ACTR10 ACTR10 POTEI POTEI POTEJ POTEJ POTEE POTEE POTEF POTEF ACTA1 ACTA1 ACTRT3 ACTRT3 ACTG2 ACTG2 ACTC1 ACTC1 ACTG1 ACTG1 ASPM ASPM MIB2 MIB2 ACTA2 ACTA2 POTED POTED ACTB ACTB MIB1 MIB1 SPEG SPEG MYLPF MYLPF ACTL9 ACTL9 UBXN2A UBXN2A ACTL10 ACTL10 ACTL7A ACTL7A OBSCN OBSCN CASK CASK GRIN1 GRIN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTR10Actin related protein 10 homolog; Belongs to the actin family (417 aa)
MIB1E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits [...] (1006 aa)
ACTR1BBeta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins (376 aa)
ACTC1Actin, alpha cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family (377 aa)
POTEDPOTE ankyrin domain family member D; Belongs to the POTE family (584 aa)
SPEGStriated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; I-set domain containing (3267 aa)
UBXN2AUBX domain-containing protein 2A; UBX domain containing (259 aa)
ACTL9Actin-like protein 9; Actin related proteins (416 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle; EF-hand domain containing (169 aa)
ACTL10Actin-like protein 10; Actin related proteins; Belongs to the actin family (245 aa)
ACTRT3Actin related protein T3 (372 aa)
ACTL7AActin-like protein 7A; Actin related proteins; Belongs to the actin family (435 aa)
ACTBActin, cytoplasmic 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
POTEFPOTE ankyrin domain family member F; In the C-terminal section; belongs to the actin family (1075 aa)
ACTA1Actin, alpha skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
ASPMAbnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] (3477 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily (943 aa)
CASKPeripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1; In the N-terminal section; belongs to the protein kinase s [...] (921 aa)
ACTG2Actin, gamma-enteric smooth muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa)
POTEJPOTE ankyrin domain family member J; In the N-terminal section; belongs to the POTE family (1038 aa)
POTEIPOTE ankyrin domain family member I; In the N-terminal section; belongs to the POTE family (1075 aa)
ACTA2Actin, aortic smooth muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family (377 aa)
MIB2E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors; Ankyrin repeat domain containing (1070 aa)
POTEEPOTE ankyrin domain family member E; In the C-terminal section; belongs to the actin family (1075 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing (8923 aa)
ACTG1Actin, cytoplasmic 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family (375 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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