| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP1A2 | ROGDI | ENSP00000354490 | ENSP00000322832 | Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.409 |
| ATP2A1 | MYH7 | ENSP00000349595 | ENSP00000347507 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.481 |
| DISC1 | ROGDI | ENSP00000355593 | ENSP00000322832 | Disrupted in schizophrenia 1 protein; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, includi [...] | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.401 |
| DMXL1 | DMXL2 | ENSP00000439479 | ENSP00000441858 | DmX-like protein 1; WD repeat domain containing | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.569 |
| DMXL1 | WDR7 | ENSP00000439479 | ENSP00000254442 | DmX-like protein 1; WD repeat domain containing | WD repeat-containing protein 7; Armadillo-like helical domain containing | 0.548 |
| DMXL2 | DMXL1 | ENSP00000441858 | ENSP00000439479 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | DmX-like protein 1; WD repeat domain containing | 0.569 |
| DMXL2 | WDR7 | ENSP00000441858 | ENSP00000254442 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | WD repeat-containing protein 7; Armadillo-like helical domain containing | 0.900 |
| MYH7 | ATP2A1 | ENSP00000347507 | ENSP00000349595 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily | 0.481 |
| MYH7 | MYH8 | ENSP00000347507 | ENSP00000384330 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Myosin-8; Muscle contraction; Myosin heavy chains | 0.907 |
| MYH8 | MYH7 | ENSP00000384330 | ENSP00000347507 | Myosin-8; Muscle contraction; Myosin heavy chains | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.907 |
| ROGDI | ATP1A2 | ENSP00000322832 | ENSP00000354490 | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | 0.409 |
| ROGDI | DISC1 | ENSP00000322832 | ENSP00000355593 | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | Disrupted in schizophrenia 1 protein; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, includi [...] | 0.401 |
| WDR7 | DMXL1 | ENSP00000254442 | ENSP00000439479 | WD repeat-containing protein 7; Armadillo-like helical domain containing | DmX-like protein 1; WD repeat domain containing | 0.548 |
| WDR7 | DMXL2 | ENSP00000254442 | ENSP00000441858 | WD repeat-containing protein 7; Armadillo-like helical domain containing | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.900 |
