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  • 11.0 [archived version]
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PPM1G PPM1G ZNF512 ZNF512 RRP8 RRP8 GPRASP2 GPRASP2 NPM1 NPM1 RPL18 RPL18 TIMM13 TIMM13 RPP25 RPP25 RPS6 RPS6 C3orf17 C3orf17 RPLP2 RPLP2 RPP40 RPP40 G3BP2 G3BP2 RPP38 RPP38 POP7 POP7 POP4 POP4 RPP30 RPP30 RPP14 RPP14 C18orf21 C18orf21 POP1 POP1 RPP25L RPP25L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIMM13Mitochondrial import inner membrane translocase subunit Tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins s [...] (95 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
NPM1Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. [...] (294 aa)
RPP25LRibonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP (163 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (140 aa)
RPP25Ribonuclease P protein subunit p25; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA (199 aa)
C3orf17Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development (567 aa)
RPLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; L ribosomal proteins (115 aa)
PPM1GProtein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family (546 aa)
ZNF512Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type (567 aa)
G3BP2Ras GTPase-activating protein-binding protein 2; Probable scaffold protein that may be involved in mRNA transport; RNA binding motif containing (482 aa)
RPP40Ribonuclease P protein subunit p40; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (363 aa)
RPS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; S ribosomal proteins (249 aa)
POP1Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP (1024 aa)
RPP30Ribonuclease P protein subunit p30; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (322 aa)
RPP14Ribonuclease P protein subunit p14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (124 aa)
GPRASP2G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors; Belongs to the GPRASP family (838 aa)
RPL1860S ribosomal protein L18; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL18 family (188 aa)
POP4Ribonuclease P protein subunit p29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P (220 aa)
C18orf21UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 (220 aa)
RPP38Ribonuclease P protein subunit p38; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus; Belongs to the eukaryotic ribosomal protein eL8 family (283 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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