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  • 11.0 [archived version]
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CMTM4 CMTM4 CKLF-CMTM1 CKLF-CMTM1 MARVELD1 MARVELD1 CMTM5 CMTM5 CMTM1 CMTM1 AMD1 AMD1 DESI2 DESI2 CMTM3 CMTM3 CKLF CKLF PLP2 PLP2 DESI1 DESI1 MAL2 MAL2 CMTM2 CMTM2 MYADM MYADM CMTM7 CMTM7 PLLP PLLP CMTM8 CMTM8 CMTM6 CMTM6 STARD7 STARD7 MYADML2 MYADML2 GLTP GLTP MAL MAL ASPSCR1 ASPSCR1 SHKBP1 SHKBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CMTM6CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family (183 aa)
PLLPPlasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family (182 aa)
DESI1Desumoylating isopeptidase 1; Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity); Belongs to the DeSI family (168 aa)
CKLFChemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa)
CMTM2CKLF like MARVEL transmembrane domain containing 2; Belongs to the chemokine-like factor family (248 aa)
SHKBP1SH3KBP1-binding protein 1; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation; Belongs to the KCTD3 family (707 aa)
DESI2Desumoylating isopeptidase 2; Protease which may deconjugate SUMO from some substrate proteins; Desumoylating isopeptidases (194 aa)
ASPSCR1Tether containing UBX domain for GLUT4; Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT; UBX domain containing (647 aa)
CMTM8CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
MALMyelin and lymphocyte protein; Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function; Belongs to the MAL family (153 aa)
GLTPGlycolipid transfer protein; Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (209 aa)
CMTM4CKLF like MARVEL transmembrane domain containing 4 (234 aa)
CMTM7CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family (175 aa)
STARD7StAR-related lipid transfer protein 7, mitochondrial; May play a protective role in mucosal tissues by preventing exaggerated allergic responses; StAR related lipid transfer domain containing (370 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5; Belongs to the chemokine-like factor family (223 aa)
AMD1S-adenosylmethionine decarboxylase proenzyme; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family (334 aa)
PLP2Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium (152 aa)
CMTM1CKLF like MARVEL transmembrane domain containing 1 (286 aa)
MYADMMyeloid associated differentiation marker; Belongs to the MAL family (322 aa)
MYADML2Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2 (307 aa)
CMTM3CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family (182 aa)
MARVELD1MARVEL domain-containing protein 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (173 aa)
CKLF-CMTM1CKLF-CMTM1 readthrough (168 aa)
MAL2Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (176 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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