node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | CGB | ENSP00000482232 | ENSP00000349954 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family | 0.737 |
CGA | CGB5 | ENSP00000482232 | ENSP00000301408 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Chorionic gonadotropin beta subunit 5 | 0.521 |
CGA | CGB8 | ENSP00000482232 | ENSP00000403649 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | 0.595 |
CGA | NR5A1 | ENSP00000482232 | ENSP00000362690 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Steroidogenic factor 1; Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’- RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (B [...] | 0.457 |
CGB | CGA | ENSP00000349954 | ENSP00000482232 | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.737 |
CGB | CGB5 | ENSP00000349954 | ENSP00000301408 | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family | Chorionic gonadotropin beta subunit 5 | 0.801 |
CGB | CGB8 | ENSP00000349954 | ENSP00000403649 | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | 0.801 |
CGB5 | CGA | ENSP00000301408 | ENSP00000482232 | Chorionic gonadotropin beta subunit 5 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.521 |
CGB5 | CGB | ENSP00000301408 | ENSP00000349954 | Chorionic gonadotropin beta subunit 5 | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family | 0.801 |
CGB5 | CGB8 | ENSP00000301408 | ENSP00000403649 | Chorionic gonadotropin beta subunit 5 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | 0.837 |
CGB8 | CGA | ENSP00000403649 | ENSP00000482232 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.595 |
CGB8 | CGB | ENSP00000403649 | ENSP00000349954 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family | 0.801 |
CGB8 | CGB5 | ENSP00000403649 | ENSP00000301408 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family | Chorionic gonadotropin beta subunit 5 | 0.837 |
NR5A1 | CGA | ENSP00000362690 | ENSP00000482232 | Steroidogenic factor 1; Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’- RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (B [...] | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.457 |
NR5A2 | PPARGC1A | ENSP00000356331 | ENSP00000264867 | Nuclear receptor subfamily 5 group A member 2; Binds to the sequence element 5’-AACGACCGACCTTGAG-3’ of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development; Belongs to the nuclear hormone receptor family. NR5 [...] | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.540 |
PPARGC1A | NR5A2 | ENSP00000264867 | ENSP00000356331 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | Nuclear receptor subfamily 5 group A member 2; Binds to the sequence element 5’-AACGACCGACCTTGAG-3’ of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development; Belongs to the nuclear hormone receptor family. NR5 [...] | 0.540 |