• Version:
  • 11.0 [archived version]
STRINGSTRING
LIPK LIPK LIPF LIPF LIPN LIPN VAPA VAPA VAPB VAPB EPHX1 EPHX1 ME3 ME3 ABHD5 ABHD5 MOSPD1 MOSPD1 ME1 ME1 ME2 ME2 SMC3 SMC3 HSPB7 HSPB7 PLIN4 PLIN4 LIPA LIPA MOSPD3 MOSPD3 LIPJ LIPJ LIPM LIPM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLIN4Perilipin-4; May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity); Belongs to the perilipin family (1357 aa)
HSPB7Heat shock protein family B member 7 (170 aa)
ME2NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family (584 aa)
LIPALysosomal acid lipase/cholesteryl ester hydrolase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation; Belongs to the AB hydrolase superfamily. Lipase family (399 aa)
VAPAVesicle-associated membrane protein-associated protein A; VAMP associated protein A (294 aa)
SMC3Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (1217 aa)
ME1Malic enzyme 1 (572 aa)
MOSPD1Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation (213 aa)
LIPJLipase family member J; Belongs to the AB hydrolase superfamily. Lipase family (366 aa)
MOSPD3Motile sperm domain containing 3 (235 aa)
LIPFLipase F, gastric type; Lipases (408 aa)
LIPKLipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases (399 aa)
LIPMLipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Belongs to the AB hydrolase superfamily. Lipase family (423 aa)
LIPNLipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases (398 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity); Abhydrolase domain containing (349 aa)
VAPBVesicle-associated membrane protein-associated protein B/C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation (243 aa)
ME3NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family (604 aa)
EPHX1Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (455 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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